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  1. How Dengue Virus Infects Cells | National Institutes of ...

    www.nih.gov/.../how-dengue-virus-infects-cells

    The virus that causes dengue is transmitted by mosquitoes. Dengue fever usually starts with a fever, joint pain, rash and nausea. Without treatment, the virus can cause damage to blood and lymph vessels and lead to dengue hemorrhagic fever, which is marked by difficulty breathing, bruising and bleeding from the nose, gums or under the skin.

  2. How Dengue Fever Spreads and Affects the Human Body ...

    getcured.xyz/how-dengue-fever-spreads-and...

    Dec 15, 2017 · White Blood Cells (WBC) carrying Dengue viruses move throughout the body. This WBCs respond by producing signaling proteins such as Cytokines and Interferons which are primarily responsible for Flu-like symptoms, Fever and severe Body pains.

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  4. Dengue and severe dengue - World Health Organization

    www.who.int/news-room/fact-sheets/detail/dengue...
    • Global Burden of Dengue
    • Transmission
    • Characteristics
    • Treatment
    • Prevention and Control
    • Who Response

    The incidence of dengue has grown dramatically around the world in recent decades. A vast majority of cases are asymptomatic and hence the actual numbers of dengue cases are underreported and many cases are misclassified. One estimate indicates 390 million dengue infections per year (95% credible interval 284–528 million), of which 96 million (67–136 million) manifest clinically (with any severity of disease).1 Another study, of the prevalence of dengue, estimates that 3.9 billion people, in...

    The Aedes aegypti mosquito is the primary vector of dengue. The virus is transmitted to humans through the bites of infected female mosquitoes. After virus incubation for 4–10 days, an infected mosquito is capable of transmitting the virus for the rest of its life. Infected symptomatic or asymptomatic humans are the main carriers and multipliers of the virus, serving as a source of the virus for uninfected mosquitoes. Patients who are already infected with the dengue virus can transmit the in...

    Dengue fever is a severe, flu-like illness that affects infants, young children and adults, but seldom causes death.Dengue should be suspected when a high fever (40°C/104°F) is accompanied by 2 of the following symptoms: severe headache, pain behind the eyes, muscle and joint pains, nausea, vomiting, swollen glands or rash. Symptoms usually last for 2–7 days, after an incubation period of 4–10 days after the bite from an infected mosquito.Severe dengue is a potentially deadly complication due...

    There is no specific treatment for dengue fever.For severe dengue, medical care by physicians and nurses experienced with the effects and progression of the disease can save lives – decreasing mortality rates from more than 20% to less than 1%. Maintenance of the patient's body fluid volume is critical to severe dengue care.

    At present, the main method to control or prevent the transmission of dengue virus is to combat vector mosquitoes through: 1. preventing mosquitoes from accessing egg-laying habitats by environmental management and modification; 2. disposing of solid waste properly and removing artificial man-made habitats; 3. covering, emptying and cleaning of domestic water storage containers on a weekly basis; 4. applying appropriate insecticides to water storage outdoor containers; 5. using of personal ho...

    WHO responds to dengue in the following ways: 1. supports countries in the confirmation of outbreaks through its collaborating network of laboratories; 2. provides technical support and guidance to countries for the effective management of dengue outbreaks; 3. supports countries to improve their reporting systems and capture the true burden of the disease; 4. provides training on clinical management, diagnosis and vector control at the regional level with some of its collaborating centres; 5....

  5. New research reveals how one antibody blocks dangerous ...

    www.technology.org/2021/01/09/new-research...

    Jan 09, 2021 · One reason no effective therapeutic has been found for dengue is that the disease can be caused by one of four different virus strains (dengue virus 1, 2, 3 or 4). Having antibodies against one...

  6. Mechanisms of Immune Evasion Induced by a Complex of Dengue ...

    academic.oup.com/jid/article/201/6/923/888927

    Mar 15, 2010 · In the first mechanism, entry of DENV-antibody complexes into human monocytic cells activates negative regulators, dihydroxyacetone kinase and autophagy-related 5-autophagy-related 12, which then disrupt the retinoic acide incucible gene I and melanoma differentiation associated gene 5 signaling cascade and disable type 1 interferon production, leading to suppression of interferon-mediated antiviral responses.

    • Sukathida Ubol, Weerawat Phuklia, Siripen Kalayanarooj, Naphak Modhiran
    • 170
    • 2010
  7. Dengue fever - Symptoms and causes - Mayo Clinic

    www.mayoclinic.org/diseases-conditions/dengue...
    • Overview
    • Symptoms
    • Causes
    • Risk Factors
    • Complications
    • Prevention

    Dengue (DENG-gey) fever is a mosquito-borne disease that occurs in tropical and subtropical areas of the world. Mild dengue fever causes a high fever, rash, and muscle and joint pain. A severe form of dengue fever, also called dengue hemorrhagic fever, can cause severe bleeding, a sudden drop in blood pressure (shock) and death.Millions of cases of dengue infection occur worldwide each year. Dengue fever is most common in Southeast Asia and the western Pacific islands, but the disease has bee...

    Many people, especially children and teens, may experience no signs or symptoms during a mild case of dengue fever. When symptoms do occur, they usually begin four to seven days after you are bitten by an infected mosquito.Dengue fever causes a high fever — 104 F degrees — and at least two of the following symptoms: 1. Headache 2. Muscle, bone and joint pain 3. Nausea 4. Vomiting 5. Pain behind the eyes 6. Swollen glands 7. RashMost people recover within a week or so. In some cases, symptoms...

    Dengue fever is caused by any one of four types of dengue viruses spread by mosquitoes that thrive in and near human lodgings. When a mosquito bites a person infected with a dengue virus, the virus enters the mosquito. When the infected mosquito then bites another person, the virus enters that person's bloodstream.After you've recovered from dengue fever, you have immunity to the type of virus that infected you — but not to the other three dengue fever virus types. The risk of developing seve...

    Factors that put you at greater risk of developing dengue fever or a more severe form of the disease include: 1. Living or traveling in tropical areas. Being in tropical and subtropical areas increases your risk of exposure to the virus that causes dengue fever. Especially high-risk areas are Southeast Asia, the western Pacific islands, Latin America and the Caribbean. 2. Prior infection with a dengue fever virus. Previous infection with a dengue fever virus increases your risk of having seve...

    If severe, dengue fever can damage the lungs, liver or heart. Blood pressure can drop to dangerous levels, causing shock and, in some cases, death.

    One dengue fever vaccine, Dengvaxia, is currently approved for use in those ages 9 to 45 who live in areas with a high incidence of dengue fever. The vaccine is given in three doses over the course of 12 months. Dengvaxia prevents dengue infections slightly more than half the time.The vaccine is approved only for older children because younger vaccinated children appear to be at increased risk of severe dengue fever and hospitalization two years after receiving the vaccine.The World Health Or...

  8. Mechanisms of Dengue virus-induced cell death | Request PDF

    www.researchgate.net/publication/8946676...

    There is mounting evidence that dengue (DEN) virus can trigger the host cell to undergo apoptosis in a cell-dependent manner. Virally induced apoptosis contributes directly to the cytopathogenic...

  9. New antiviral mechanism for dengue therapeutics -- ScienceDaily

    www.sciencedaily.com/releases/2020/07/...

    Jul 13, 2020 · Dengue is common in more than 100 countries and forty percent of the world's population is at risk of infection. When someone becomes ill with dengue, symptoms that can range from mild to severe...

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