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  1. Receptors and routes of dengue virus entry into the host ...

    academic.oup.com/femsre/article/39/2/155/635122

    The increasing number of dengue cases and the changes in the geographic distribution of the disease over the last two decades stimulated the scientific community to research on dengue virus (DENV). The disease caused by this member of the Flaviviridae family is a major international health threat now spreading from tropical and subtropical ...

  2. Mechanism of Dengue Virus Entry into Cells

    globalbiodefense.com/2014/02/26/mechanism-of...

    Feb 26, 2014 · Mechanism of Dengue Virus Entry into Cells by Global Biodefense Staff February 26, 2014, 2:48 pm Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash.

  3. SUMMARY Much remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans. They may range from subclinical infection to dengue fever, dengue hemorrhagic fever (DHF), and eventually dengue shock syndrome (DSS). As both cell tropism and tissue tropism of DENV are considered major determinants in the pathogenesis of dengue, there is a ...

  4. Mechanism of dengue virus entry into cells uncovered by ...

    www.sciencedaily.com/releases/2014/02/...

    Mechanism of dengue virus entry into cells uncovered by research Date: February 17, 2014 Source: Biophysical Society Summary: Despite its heavy toll, the prevention and clinical treatment of ...

  5. Mechanisms of Immune Evasion Induced by a Complex of Dengue ...

    academic.oup.com/jid/article/201/6/923/888927

    Mar 15, 2010 · Dengue is caused by a single-stranded RNA virus, the dengue virus (DENV), which exists as 4 closely related serotypes. During the past decades, DENV have evolved into one of the world's major arthropod-borne viruses, a fact that is revealed by the dramatically increasing number of dengue cases not only in areas where the virus is endemic but also among travelers who have visited tropical ...

  6. Dengue virus non-structural protein 1: a pathogenic factor ...

    jbiomedsci.biomedcentral.com/articles/10.1186/s...

    Jul 24, 2018 · Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection. DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Hemorrhage and vascular leakage are two characteristic symptoms of DHF/DSS. However, due to the limited understanding of dengue pathogenesis, no satisfactory therapies to treat nor vaccine to ...

  7. How Dengue Virus Infects Cells | National Institutes of ...

    www.nih.gov/.../how-dengue-virus-infects-cells

    The virus that causes dengue is transmitted by mosquitoes. Dengue fever usually starts with a fever, joint pain, rash and nausea. Without treatment, the virus can cause damage to blood and lymph vessels and lead to dengue hemorrhagic fever, which is marked by difficulty breathing, bruising and bleeding from the nose, gums or under the skin.

  8. Replication of Dengue Virus - Microbiology Notes

    microbiologynotes.com/replication-of-dengue-virus

    Apr 20, 2016 · Replication of Dengue Virus Dengue Virus enters host cells by receptor-mediated endocytosis, which involves binding through the interaction between the surface proteins of virion (E) and cellular receptors on the surface of target cell. Once the virus has entered a host cell, the virus penetrates deeper into the cell and remains inside the endosome. Two conditions are needed for the ...

  9. Dengue - The Lancet

    www.thelancet.com/journals/lancet/article/PIIS...

    Mortality from severe dengue is low, but the economic and resource burden on health services remains substantial in endemic settings. Unfortunately, progress towards development of effective therapeutics has been slow, despite notable advances in the understanding of disease pathogenesis and considerable investment in antiviral drug discovery. For decades antibody-dependent enhancement has ...

  10. Third, increased travel by airplane provides the ideal mechanism for transporting dengue viruses between population centers of the tropics, resulting in a constant exchange of dengue viruses and other pathogens. Lastly, in most countries the public health infrastructure has deteriorated.

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