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Sep 30, 2021 · Abstract. Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one of the prominent public health problems in tropical and subtropical regions with no effective vaccines. Every year around 400 million people get infected by the Dengue virus, with a mortality rate of about 20% among the patients with severe dengue.
Nov 25, 2015 · This Review describes the role of the immune system in dengue pathogenesis. The authors also discuss new insights gained from human monoclonal antibodies against dengue virus as well as the recent ...
Sep 26, 2019 · Aedes aegypti mosquito. Dengue viruses are spread to people through the bites of infected Aedes species mosquitoes ( Ae. aegypti or Ae. albopictus ). These are the same types of mosquitoes that spread Zika and chikungunya viruses. These mosquitoes typically lay eggs near standing water in containers that hold water, like buckets, bowls, animal ...
The four closely related dengue viruses — DEN-1, DEN-2, DEN-3, and DEN-4 — are found in the same regions of the world. The dengue virus has a roughly spherical structure. It is composed of the ...
Mar 1, 2017 · This review will provide a brief account of the status of therapeutics research and development for dengue. Keywords: dengue, flavivirus, dengue drug discovery, antivirals, dengue prophylaxis, dengue therapeutics. The geographic distribution of dengue has expanded globally in the past 5 decades. This mosquito-borne acute disease is now endemic ...
Nov 25, 2015 · 4. Virulent dengue viruses. The concept of “virulent” or “non-virulent” dengue viruses developed when it was observed that the American genotype of DENV 2 did not produce a large outbreak of DHF/DSS in Iquitos, Peru, during a 1995 outbreak in a population that was highly immune to DENV 1 41, 42.
Mar 4, 2019 · The virulence difference among five DENV1 strains. (A) The replication of DENV1A-E (labeled as short form of DV1A to DV1D in the figures) in human in 293T cells. 293T cells were infected with DENV1 A to E at an MOI of 0.5, respectively. Cells were harvested at 12, 24, 48 and 72 h post infection, and viral replication efficiency were determined ...
