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1. www.ncbi.nlm.nih.gov › pmc › articlesMolecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 8, 2023 · Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection.

   • Dengue: Update on Clinically Relevant Therapeutic Strategies ...

     The DENV genome consists of a single-stranded positive-sense...

   • Current Status of Dengue Therapeutics Research and ...

     Consequently, drugs directed at the viral targets or...

2. pubmed.ncbi.nlm.nih.gov › 34020338Dengue structural proteins as antiviral drug targets: Current ...

   pubmed.ncbi.nlm.nih.gov › 34020338

   Oct 5, 2021 · In this review, the possible drug targets for discovery and development of potential antiviral drugs against structural proteins of dengue virus, the current development status of the antiviral drugs against dengue around the world, and challenges that need to be addressed to overcome the shortcomings in the process of drug discovery have been ...

   • Author: Akshatha H. S, Gurubasavaraj V. Pujar, Arun Kumar Sethu, Meduri Bhagyalalitha, Manisha Singh

   • Publish Year: 2021

3. People also ask

   Which drugs are used in clinical trials for dengue?

   • The most recent proof-of-concept clinical trials for dengue have been performed using repurposed or off-patent drugs, namely chloroquine, prednisolone, balapiravir, celgosivir, and lovastatin (Table 1 ). These trials have all used the conventional double-blinded, randomized, placebo-controlled design with clearly defined primary end points.

   Current Status of Dengue Therapeutics Research and Development

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5388029/

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   What are antiviral drug targets for dengue?

   • Antiviral drug targets for dengue The viral components of dengue can be targeted effectively to develop antiviral drugs classified as viral protein targets and viral enzyme targets. Viral protein targets can be sub-classified into structural and non-structural protein targets.

   Dengue structural proteins as antiviral drug targets: Current status in

   www.sciencedirect.com/science/article/pii/S0223523421003767

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   What are the challenges in antiviral drug discovery & development for dengue?

   • Challenges in antiviral drug discovery and development for dengue. The challenge in preclinical development is that except in humans, the rest of the animal's dengue virus does not cause any infectivity or shows a mild type of infection.

   Dengue structural proteins as antiviral drug targets: Current status in

   www.sciencedirect.com/science/article/pii/S0223523421003767

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4. www.sciencedirect.com › science › articleDengue structural proteins as antiviral drug targets: Current ...

   www.sciencedirect.com › science › article

   Oct 5, 2021 · Therefore can be a promising drug target for treating dengue viral infections. Envelope proteins are one of the widely studied structural proteins and are the most promising anti-dengue drug target. The area of interest for the treatment of dengue is mainly shifting towards peptide drugs.

   • Author: Akshatha H. S, Gurubasavaraj V. Pujar, Arun Kumar Sethu, Meduri Bhagyalalitha, Manisha Singh

   • Publish Year: 2021

5. www.sciencedirect.com › science › articleRecent advances in antiviral drug development towards dengue ...

   www.sciencedirect.com › science › article

   Aug 1, 2020 · Figure 1. DENV replication cycle. DENV infection is initiated by binding of the virus to host-cell receptors (1). The virus is then internalised via clathrin-mediated endocytosis (2) and the low pH in the endosome triggers the membrane fusion reaction (3).

6. www.nature.com › articles › d41586/021/02638-9A step towards therapeutics for dengue - Nature

   www.nature.com › articles › d41586/021/02638-9

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   Oct 6, 2021 · An effective drug against dengue virus (DENV) is urgently needed, because this mosquito-transmitted virus represents a tremendous public-health burden, with about 3.9 billion people at risk of ...