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Mar 8, 2023 · Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection.
Apr 18, 2023 · The DENV genome consists of a single-stranded positive-sense RNA that encodes for three structural (capsid, prM/M, and E) and seven non-structural proteins that are translated during the virus replication cycle [ 2 ]. The virus is spread by an infected mosquito bite during a blood meal and exists in both sylvatic and urban ecosystems [ 3 ].
Mar 1, 2017 · Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue.
Oct 5, 2021 · In this review, the possible drug targets for discovery and development of potential antiviral drugs against structural proteins of dengue virus, the current development status of the antiviral drugs against dengue around the world, and challenges that need to be addressed to overcome the shortcomings in the process of drug discovery have been ...
Oct 5, 2021 · Therefore can be a promising drug target for treating dengue viral infections. Envelope proteins are one of the widely studied structural proteins and are the most promising anti-dengue drug target. The area of interest for the treatment of dengue is mainly shifting towards peptide drugs.
Aug 1, 2020 · Figure 1. DENV replication cycle. DENV infection is initiated by binding of the virus to host-cell receptors (1). The virus is then internalised via clathrin-mediated endocytosis (2) and the low pH in the endosome triggers the membrane fusion reaction (3).
Oct 6, 2021 · An effective drug against dengue virus (DENV) is urgently needed, because this mosquito-transmitted virus represents a tremendous public-health burden, with about 3.9 billion people at risk of ...
