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May 14, 2024 · Dengue is defined by a combination of ≥2 clinical findings in a febrile person who lives in or traveled to (in the last 14 days) a dengue-endemic area. Clinical findings include nausea, vomiting, rash, aches and pains, a positive tourniquet test, leukopenia, or any warning sign.
Apr 23, 2024 · Most people with dengue have mild or no symptoms and will get better in 1–2 weeks. Rarely, dengue can be severe and lead to death. If symptoms occur, they usually begin 4–10 days after infection and last for 2–7 days. Symptoms may include: high fever (40°C/104°F) severe headache. pain behind the eyes.
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1 day ago · Normally, our immune system remembers infections and fights them off better the next time. But with dengue, if you get infected with a different type of the virus, ADE can make it worse. Instead of stopping the virus, antibodies from the first infection can help the new virus enter immune cells, rather than stopping them.
Apr 25, 2024 · Author summary Dengue, caused by dengue virus (DENV), is the most prevalent mosquito-transmitted disease in humans and a significant public health issue worldwide. DENV nonstructural protein 1 (NS1) has been shown to contribute to dengue pathogenesis through the induction of endothelial barrier dysfunction, resulting in hyperpermeability and vascular leak–a key feature of severe dengue ...
May 4, 2024 · Dengue virus (DENV) is a continuing global threat that puts half of the world’s population at risk for infection. This mosquito-transmitted virus is endemic in over 100 countries. When a mosquito takes a bloodmeal, virus is deposited into the epidermal and dermal layers of human skin, infecting a variety of permissive cells, including keratinocytes, Langerhans cells, macrophages, dermal ...
Apr 24, 2024 · In the case of dengue virus (DENV), an arbovirus that infects more than 100 million people each year, the situation is even more complex (4, 5). Individuals with high DENV antibody titers are protected from infection and developing severe disease (6–8).
Apr 25, 2024 · To determine vaccine efficacy, six vaccinees and four unvaccinated volunteers were challenged with a partially attenuated dengue virus-1 strain at a median time of 2 years after completion of the prime-boost vaccine regimen. Instead of protection, the authors found signs suggestive of antibody-dependent enhancement in four (67%) of six vaccinees.
