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1. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Understanding of the Pathogenesis of Dengue Virus...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility.

2. www.ncbi.nlm.nih.gov › pmc › articlesProduction, Transmission, Pathogenesis, and Control of Dengue ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 15, 2021 · Phospholipase A 2, a chemical constituent of Crotalus durissus terrificus venom, was inhibited dengue virus and yellow fever virus infection in Vero cells, inducing a partial exposure of genomic RNA through glycerophospholipids cleavage . Tomatidine has inhibited dengue virus mainly at late stages of infection towards all dengue virus serotypes ...

   • DOI: 10.1155/2021/4224816
   • Published: 2021

   • Publication: Biomed Res Int. 2021; 2021: 4224816.

3. People also ask

   What causes severe manifestations of dengue virus disease?

   • The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in different hosts, which cannot be explained by a single hypothesis alone.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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   What is the pathogenesis of dengue?

   • The pathogenesis of dengue was attributed to various viral and host factors such as non-structural protein 1 (NS1) viral antigen, DENV genome variation, subgenomic RNA, antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies and autoimmunity.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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   What factors are involved in the pathogenesis of dengue virus infection?

   • 1. Summary of various factors implicated in pathogenesis of dengue virus infection Higher viremia levels of DENV-2 and DENV-3 in secondary infections. Inhibits antiviral genes and enhancing the production of IL-10. Apart from various viral factors implicated in the pathogenesis of DENV infection, host genetic factors also play an important role.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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4. www.ncbi.nlm.nih.gov › pmc › articlesMolecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 8, 2023 · Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the urgent demand for the development of novel anti-DENV therapeutics.

   • DOI: 10.3390/v15030705
   • Published: 2023/03

   • Publication: Viruses. 2023 Mar; 15(3): 705.

5. www.sciencedirect.com › science › articleMolecular mechanisms in the pathogenesis of dengue infections

   www.sciencedirect.com › science › article

   May 1, 2024 · Dengue is the most rapidly emerging climate-sensitive infection, and there has been a 10-fold rise in cases over the past 20 years. Severe illness is characterized by vascular leakage, organ dysfunction, and severe bleeding which occur due to the direct effects of the viral non-structural protein NS1 and an aberrant host immune response.

6. www.nature.com › articles › s41577/019/0123-xAdaptive immune responses to primary and secondary dengue ...

   www.nature.com › articles › s41577/019/0123-x

   Jan 24, 2019 · Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the circulation of multiple serotypes, global expansion of the disease and recent gains in vaccination coverage, pre ...

   • Author: Ashley L St John, Ashley L St John, Abhay P S Rathore

   • Publish Year: 2019

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8. www.sciencedirect.com › science › articleDengue virus infection – a review of pathogenesis, vaccines ...

   www.sciencedirect.com › science › article

   Jan 15, 2023 · Taking the neutralization mechanism in West Nile Virus as example, the mechanism was known as a “multiple hit” model (Pierson et al., 2007), which is also similar with the neutralization in other viruses using the virion “coating” by antibodies model (Burton et al., 2001). The neutralization effect is dependent on the concentration of ...

9. www.cell.com › trends › molecular-medicineMolecular mechanisms in the pathogenesis of dengue infections

   www.cell.com › trends › molecular-medicine

   Current dengue landscape and disease burden Dengue is the most common mosquito-borne viral infection and was listed as one of the top 10 threats to global health by the World Health Organization (WHO) in 2019i. Half of the global pop-ulation is at risk of infection with dengue virus (DENV), resulting in 390 million infections annually [1].