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1. jbiomedsci.biomedcentral.com › articles › 10Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com › articles › 10

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   Apr 22, 2024 · Whenever the dengue virus infects the human host, both the innate (interferons, complement system, etc.) and adaptive (immunoglobulins and cytotoxic T-cells) immune systems are stimulated to neutralize the virus.

2. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Understanding of the Pathogenesis of Dengue Virus ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility.

   • Author: Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar, Govindakarnava...
   • DOI: 10.1007/s00284-020-02284-w

   • Publish Year: 2021
   • Publication: Curr Microbiol. 2021; 78(1): 17-32.

3. People also ask

   How does a dengue virus interact with the host cellular machinery?

   • During dengue infection, the virus interacts with the host cellular machinery responsible for 5’ capping. DENV employs multiple strategies to hijack and manipulate this process. For instance, the virus sequesters essential host factors involved in capping, such as the cap-binding complex and associated enzymes.

   Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01030-9

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   How does a dengue virus internalize?

   • D Envelope glycoproteins attach to host receptors and form the dengue-host membrane complex, resulting in virus internalization to process its replication and propagation inside the host cell [ 13] Humans and mosquitoes are the primary hosts and vectors of DENV, respectively.

   Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01030-9

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   What causes severe manifestations of dengue virus disease?

   • The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in different hosts, which cannot be explained by a single hypothesis alone.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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4. www.ncbi.nlm.nih.gov › pmc › articlesProduction, Transmission, Pathogenesis, and Control of Dengue ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 15, 2021 · 1. Introduction. Dengue regards one of the utmost serious arboviral infections around the world. dengue virus (DENV) is transmitted through bites of female Aedes mosquitos especially Aedes (Stegomyia) aegypti, Ae. alpopictus [ 1 ], Ae. niveus, and Ae. polynesiensis [ 2 ].

   • DOI: 10.1155/2021/4224816
   • Published: 2021

   • Publication: Biomed Res Int. 2021; 2021: 4224816.

5. www.ncbi.nlm.nih.gov › pmc › articlesMolecular mechanism of pathogenesis of dengue virus: Entry ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Interaction with specific receptor (s) at the cell surface is one of the first events in the pathogenesis of Dengue virus. However, relatively little is known about these receptors. Cellular receptors in human monocytes and mouse neural cells are main target for the viral infection.

   • Author: Seema, S. K. Jain

   • Publish Year: 2005

6. www.nature.com › scitable › topicpageDengue Viruses | Learn Science at Scitable - Nature

   www.nature.com › scitable › topicpage

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   The dengue virus attaches to the surface of a host cell and enters the cell by a process called endocytosis. Once deep inside the cell, the virus fuses with the endosomal membrane and is released ...

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8. www.nejm.org › doi › fullDengue | New England Journal of Medicine

   www.nejm.org › doi › full

   Apr 12, 2012 · Although most dengue virus infections are asymptomatic, a wide variety of clinical manifestations may occur, ranging from mild febrile illness to severe and fatal disease. 1 The differential ...

9. www.sciencedirect.com › science › articleMolecular mechanisms in the pathogenesis of dengue infections

   www.sciencedirect.com › science › article

   May 1, 2024 · Bleeding following dengue virus infection occurs due to multiple mechanisms including platelet activation by NS1, serotonin, and PAF, accompanied by a wide range of other coagulation abnormalities. Abstract.