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1. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Understanding of the Pathogenesis of Dengue Virus...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 24, 2020 · The pathogenesis of dengue was attributed to various viral and host factors such as non-structural protein 1 (NS1) viral antigen, DENV genome variation, subgenomic RNA, antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies and autoimmunity.

2. jbiomedsci.biomedcentral.com › articles › 10Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com › articles › 10

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   Apr 22, 2024 · Multifunctional RNA-binding proteins (RBPs) such as G3BP1 (G3BP Stress Granule Assembly Factor 1), G3BP2 (G3BP Stress Granule Assembly Factor 2), and Caprin1 are identified as novel regulators during Dengue virus type 2 (DENV-2) infection.

3. People also ask

   How does a dengue virus interact with the host cellular machinery?

   • During dengue infection, the virus interacts with the host cellular machinery responsible for 5’ capping. DENV employs multiple strategies to hijack and manipulate this process. For instance, the virus sequesters essential host factors involved in capping, such as the cap-binding complex and associated enzymes.

   Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01030-9

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   What is the pathophysiology of dengue virus infection (DHF/DSS)?

   • The pathogenesis of dengue virus infection and severe dengue manifestations is very complex and not completely understood. The pathophysiological hallmark of DHF/DSS is plasma leakage and deranged hemostasis.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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   Which cytokines are responsible for severe dengue pathogenesis?

   • Apart from NS1 protein, anti-DENV NS1 antibodies were believed to be responsible for pathogenesis of severe dengue. A major factor that is considered responsible for severe dengue pathogenesis is disorganized release of cytokines. Several cytokines and chemokines are secreted by the human endothelial cells, in response to anti-DENV NS1 antibodies.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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4. www.ncbi.nlm.nih.gov › pmc › articlesMolecular mechanism of pathogenesis of dengue virus: Entry ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Interaction with specific receptor (s) at the cell surface is one of the first events in the pathogenesis of Dengue virus. However, relatively little is known about these receptors. Cellular receptors in human monocytes and mouse neural cells are main target for the viral infection.

   • Author: Seema, S. K. Jain

   • Publish Year: 2005

5. www.ncbi.nlm.nih.gov › pmc › articlesStructures and Dynamics of Dengue Virus Nonstructural ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 17, 2022 · Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins. Four of the seven nonstructural proteins, NS2A, NS2B, NS4A and NS4B, are membrane proteins.

   • Author: Qingxin Li, Congbao Kang
   • Publication: Membranes (Basel). 2022 Feb; 12(2): 231.

   • DOI: 10.3390/membranes12020231
   • Published: 2022/02

6. journals.sagepub.com › doi › 10Dengue Virus: Molecular Biology and Recent Developments in ...

   journals.sagepub.com › doi › 10

   Nov 19, 2023 · The Life Cycle of Dengue Virus. (Dengue virus enters the host by receptor-mediated endocytosis, which subsequently results in the fusion of vesicular and viral membranes. This fusion allows the secretion of genomic RNA into the cytoplasm, which plays a role as mRNA for replication and translation.

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8. www.sciencedirect.com › science › articleMolecular mechanisms in the pathogenesis of dengue infections

   www.sciencedirect.com › science › article

   May 1, 2024 · In this review we discuss the molecular mechanisms of dengue pathogenesis and highlight recent developments and gaps in our knowledge which are important for the identification of dengue biomarkers and drug targets.

9. www.nature.com › articles › s41577/019/0123-xAdaptive immune responses to primary and secondary dengue ...

   www.nature.com › articles › s41577/019/0123-x

   Jan 24, 2019 · The three structural proteins (capsid, E and prM/M) plus seven non-structural proteins are transcribed and translated during viral replication 2, making them accessible to antigen-processing...