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Nov 24, 2020 · The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in different hosts, which cannot be explained by a single hypothesis alone.
- Figure - PMC - National Center for Biotechnology Information
The pathogenesis of dengue virus infection is attributed to...
- Production, Transmission, Pathogenesis, and Control of Dengue ...
Naringenin (citrus flavanone) was evaluated against dengue...
- Dengue virus infection: current concepts in immune mechanisms ...
The structural proteins – core, pre-membrane and envelope –...
- Figure - PMC - National Center for Biotechnology Information
Aug 14, 2023 · DENVs bind via the E glycoprotein to viral receptors on the cell surface, which may include heparan sulfate or lectins such as DC-SIGN and CLEC5A [ 6-8 ]; they can also bind to cell surface immunoglobulin receptors in the presence of antibodies to the E glycoprotein or precursor membrane (pre-M) protein, as described further below [ 9 ].
Apr 22, 2024 · This review aims to summarize the complex interaction between DENV and the host cellular machinery, comprising regulatory mechanisms at various molecular levels such as epigenetic modulation of the host genome, transcription of host genes, translation of viral and host mRNAs, post-transcriptional regulation of the host transcriptome, post-transl...
Apr 12, 2012 · DOI: 10.1056/NEJMra1110265. VOL. 366 NO. 15. Dengue is a self-limited, systemic viral infection transmitted between humans by mosquitoes. The rapidly expanding global footprint of dengue is a ...
Abstract. The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility.
