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1. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Status of Dengue Therapeutics Research and Development

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 1, 2017 · Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue.

   • Table - PMC - National Center for Biotechnology Information

     List of Clinical Studies on Dengue Therapeutics. Compound...

   • Molecular Mechanisms of Antiviral Agents against Dengue Virus

     Various antiviral agents have been developed and...

   • Current Trends and Limitations in Dengue Antiviral Research

     Table 1 shows a list of compounds that target the dengue...

   • Dengue structural proteins as antiviral drug targets: Current ...

     Antiviral Agents. Viral Structural Proteins. Dengue virus...

2. www.sciencedirect.com › science › articleDengue structural proteins as antiviral drug targets: Current ...

   www.sciencedirect.com › science › article

   Oct 5, 2021 · The list of compounds is under the drug development stage shown in Fig. 6 and their mechanism of action in Table 2 α1-α1′ helix is positively charged and involved in membrane interactions. Byrd, C. M. and co-workers targeted this site with ST-148 compound.

   • Author: Akshatha H. S, Gurubasavaraj V. Pujar, Arun Kumar Sethu, Meduri Bhagyalalitha, Manisha Singh

   • Publish Year: 2021

3. People also ask

   What are antiviral drug targets for dengue?

   • Antiviral drug targets for dengue The viral components of dengue can be targeted effectively to develop antiviral drugs classified as viral protein targets and viral enzyme targets. Viral protein targets can be sub-classified into structural and non-structural protein targets.

   Dengue structural proteins as antiviral drug targets: Current status in

   www.sciencedirect.com/science/article/pii/S0223523421003767

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   Which drugs are used in clinical trials for dengue?

   • The most recent proof-of-concept clinical trials for dengue have been performed using repurposed or off-patent drugs, namely chloroquine, prednisolone, balapiravir, celgosivir, and lovastatin (Table 1 ). These trials have all used the conventional double-blinded, randomized, placebo-controlled design with clearly defined primary end points.

   Current Status of Dengue Therapeutics Research and Development

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5388029/

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   What are the challenges in antiviral drug discovery & development for dengue?

   • Challenges in antiviral drug discovery and development for dengue. The challenge in preclinical development is that except in humans, the rest of the animal's dengue virus does not cause any infectivity or shows a mild type of infection.

   Dengue structural proteins as antiviral drug targets: Current status in

   www.sciencedirect.com/science/article/pii/S0223523421003767

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4. www.nature.com › articles › d41586/021/02638-9A step towards therapeutics for dengue - Nature

   www.nature.com › articles › d41586/021/02638-9

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   Oct 6, 2021 · 06 October 2021. A step towards therapeutics for dengue. Finding a treatment for dengue, the most prevalent mosquito-borne viral disease in humans, has been difficult. A compound called...

5. www.sciencedirect.com › science › articleRecent advances in antiviral drug development towards dengue ...

   www.sciencedirect.com › science › article

   Aug 1, 2020 · Figure 1. DENV replication cycle. DENV infection is initiated by binding of the virus to host-cell receptors (1). The virus is then internalised via clathrin-mediated endocytosis (2) and the low pH in the endosome triggers the membrane fusion reaction (3).