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Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14 days after infection.
Aug 1, 2016 · Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5). This essential enzymatic activity renders the RdRp attractive for antiviral therapy. NS5 synthesizes viral RNA via a “de novo” initiation mechanism. Crystal structures of ...
Feb 17, 2022 · 2.4. Dengue Virus NS4B. Dengue virus NS4B is a membrane protein consisting of 248 residues with a molecular weight of approximately 27 kDa (Figure 5 A). It is an important component of the viral replication complex on the ER membrane and colocalized with NS3 and viral double-stranded RNA [123,124,125,126]. The 2K peptide preceding NS4B can be ...
Apr 18, 2023 · Dengue risk factors. Secondary heterologous dengue infection is the most well-established risk factor for severe dengue. This is thought to be attributable to antibody-dependent enhancement of infection (ADE), which occurs when viruses bound to sub-neutralizing antibodies are opsonized by immune cells like dendritic cells, monocytes/macrophages through Fc receptor, which then results in ...
Mar 16, 2021 · Introduction. Infectious diseases are well known since ancient time to human civilisation. Infectious disease are caused due to different microorganisms (bacteria, viruses and fungi). 1 Viral structure is simple and consists of a protein coat, nucleic acid, viral enzymes and, sometimes, a lipid envelope, unlike the complex structure of fungi, helminths and protozoa.
Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the urgent demand for the development of novel anti-DENV therapeutics. Various antiviral agents have been developed and investigated for their anti ...
Aug 8, 2016 · Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non ...
