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The antiviral mechanism of action of iminosugars against many enveloped viruses, including dengue virus (DENV), HIV, influenza and hepatitis C virus, is believed to be mediated by inducing misfolding of viral N-linked glycoproteins through inhibition of host endoplasmic reticulum-resident α-glucosidase enzymes.
Jun 10, 2021 · Recent field trials have demonstrated that dengue incidence can be substantially reduced by introgressing strains of the endosymbiotic bacterium Wolbachia into Aedes aegypti mosquito populations. This strategy relies on Wolbachia reducing the susceptibility of Ae. aegypti to disseminated infection by positive-sense RNA viruses like dengue.
Aug 7, 2014 · Nitazoxanide is a broad-spectrum antiviral in Phase 3 trials for treating influenza. In a Phase 2/3 trial, oral nitazoxanide reduced the duration of influenza symptoms. Treatment with oral nitazoxanide also reduced shedding of influenza virus. Data suggest a role in treating a broader spectrum of viral respiratory infections.
Nov 19, 2021 · 4.3. Dengue Virus. Regarding the activities of curcumin against arboviruses, it has been shown that curcumin inhibits dengue virus propagation in a dose-dependent manner that might be due to an increase of Lys48 ubiquitin-conjugated proteins and accumulation of viral proteins.
Mar 8, 2023 · This review discusses the mechanisms of action employed by various antiviral agents against DENV. The development of host-directed antivirals targeting host receptors and direct-acting antivirals targeting DENV structural and non-structural proteins are reviewed. In addition, the development of antivirals that target different stages during ...
Oct 17, 2018 · GILT can break disulfide bonds within the envelope protein of several endocytosed viruses, including murine leukemia virus (MLV), vesicular stomatitis virus (VSV), and HIV-1 HXB2 strain. Since the Env protein is critical for the endosome-to-cytoplasm transition, the action of GILT inhibits viral entry and subsequent viral replication ( 62 , 63 ).
Oct 6, 2021 · Janssen Announces Novel Mechanism of Action that Shows Promise Against Dengue in Data Published in Nature Early-stage research suggests potential to prevent and treat all dengue serotypes With no treatments available, dengue infects up to 400 million people each year and the pace of outbreaks is increasing.[1]
