Jun 17, 2014 · Dengue viruses (DV) represent a significant global health burden, with up to 400 million infections every year and around 500,000 infected individuals developing life-threatening disease. In spite of attempts to develop vaccine candidates and antiviral drugs, there is a lack of approved therapeutics for the treatment of DV infection.
- Pietro Scaturro, Iuni Margaret Laura Trist, David Paul, Anil Kumar, Eliana G. Acosta, Chelsea M. Byr...
Interaction with specific receptor(s) at the cell surface is one of the first events in the pathogenesis of Dengue virus. However, relatively little is known about these receptors. Cellular receptors in human monocytes and mouse neural cells are main target for the viral infection. The envelope protein of the virus (E-protein) plays important role in attachment of virus to target cells and their interaction with cellular receptors.
- Seema, S. K. Jain
Dengue virus is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. Five serotypes of the virus have been found, all of which can cause the full spectrum of disease. Nevertheless, scientists' understanding of dengue virus may be simplistic, as rather than distinct antigenic groups, a continuum appears to exist. This same study identified 47 strains of dengue virus. Additionally, coinfection with and lack of rapid tes
Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash.
Feb 26, 2014 · Mechanism of Dengue Virus Entry into Cells. Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash. In some people the disease progresses to a severe, often fatal, form known as dengue hemorrhagic fever.
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Apr 20, 2016 · Dengue Virus enters host cells by receptor-mediated endocytosis, which involves binding through the interaction between the surface proteins of virion (E) and cellular receptors on the surface of target cell. Once the virus has entered a host cell, the virus penetrates deeper into the cell and remains inside the endosome.
Dengue virus (DENV) antibody-dependent enhancement of infection upregulates the production of anti-inflammatory cytokines, but suppresses anti-DENV free radical and pro-inflammatory cytokine production, in THP-1 cells. J. Gen. Virol. 88: 365-375.
- Byron E. E. Martina, Penelope Koraka, Albert D. M. E. Osterhaus
For other uses, see Dengue fever (disambiguation). Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash.
Dengue virus (DENV) infections are expanding worldwide and, because of the lack of a vaccine, the search for antiviral products is imperative. Four serotypes of DENV are described and they all cause a similar disease outcome. It would be interesting to develop an antiviral product that can interact with all four serotypes, prevent host cell infection and subsequent immune activation. DENV ...
- Marijke M. F. Alen, Dominique Schols
The antiviral mechanism of action of iminosugars against many enveloped viruses, including dengue virus (DENV), HIV, influenza and hepatitis C virus, is believed to be mediated by inducing misfolding of viral N -linked glycoproteins through inhibition of host endoplasmic reticulum-resident α-glucosidase enzymes.
- Joanna L. Miller, Beatrice E. Tyrrell, Nicole Zitzmann