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Mar 3, 2002 · The overall fit of the 90 TBEV E dimer structures to the cryoEM map of dengue virus gives a satisfying, close-packing arrangement (Figures 3B and 3D). The dengue virus structure (Figure 3C) has sets of three, nearly parallel dimers. These sets associate to form a “herringbone” configuration on the viral surface.
Aug 30, 2013 · Dengue is an acute febrile disease caused by the mosquito-borne dengue viruses (DENVs), consisting of four serotypes (DENV 1 to 4), that are members of the family, genus flavivirus ( 1 ). All four DENV serotypes have emerged from sylvatic strains in the forests of South-East Asia ( 2 ).
Mar 29, 2019 · 37 Altmetric. Metrics. Dengue (DENV) and Zika (ZIKV) viruses are clinically important members of the Flaviviridae family with an 11 kb positive strand RNA genome that folds to enable virus...
Evolution. Lifecycle. Genome. Structural and enzymatic proteins. E protein. prM/M protein. NS3 protein. NS4A protein. NS5 protein. Complexes between the E protein and neutralizing antibodies. Disease. Mechanism of infection. Severe disease. Immune system interaction. Inhibition of interferon signaling by blocking signal transducer.
May 17, 2021 · Structural landscape of the complete genomes of dengue virus serotypes and other viral hemorrhagic fevers. Riccardo Delli Ponti & Marek Mutwil. BMC Genomics 22, Article number: 352 ( 2021 ) Cite this article. 1793 Accesses. 4 Citations. 4 Altmetric. Metrics. Abstract. Background.
Abstract. The genomes of RNA viruses encode the information required for replication in host cells both in their linear sequence and in complex higher-order structures. A subset of these RNA genome structures show clear sequence conservation, and have been extensively described for well-characterized viruses.
Feb 17, 2022 · Dengue virus NS4B is a membrane protein consisting of 248 residues with a molecular weight of approximately 27 kDa ( Figure 5 A). It is an important component of the viral replication complex on the ER membrane and colocalized with NS3 and viral double-stranded RNA [ 123, 124, 125, 126 ].
