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     mdpi.com

     • DENV passively escapes from innate immunity surveillance and also actively subverts the innate immune system at multiple steps. DENV targets both RNA-triggered RLR-mitochondrial antiviral signaling protein (RLR-MAVS) and DNA-triggered cGAS-STING signaling to reduce IFN production in infected cells.
     pubmed.ncbi.nlm.nih.gov › 30564245

     How Dengue Virus Circumvents Innate Immunity - PubMed

2. People also ask

   What is the innate antiviral response to dengue virus (DENV)?

   • The innate antiviral response to dengue virus (DENV) is implemented by a variety of immune cells and inflammatory mediators. If these components are in balance, viral clearance is efficient and, consequently, infections will be asymptomatic or will only have mild clinical manifestations.

   Innate Immune Response to Dengue Virus: Toll-like Receptors and

   www.ncbi.nlm.nih.gov/pmc/articles/PMC9147118/

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   How does the dengue virus affect white blood cells?

   • Normally, monocytes and macrophages ingest and destroy pathogens, but instead of destroying the dengue virus, both types of white blood cells are targeted and infected by the virus. The dengue virus tricks the immune system to get around its defenses and infect more cells.

   Host Response to the Dengue Virus | Learn Science at Scitable - Nature

   www.nature.com/scitable/topicpage/host-response-to-the-dengue-virus-22402106/

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   What factors affect the clinical outcome of dengue?

   • Viral and host factors are related to the clinical outcome of dengue, although the disease pathogenesis remains uncertain. The innate antiviral response to DENV is implemented by a variety of immune cells and inflammatory mediators. Blood monocytes, dendritic cells (DCs) and tissue macrophages are the main target cells of DENV infection.

   Innate Immune Response to Dengue Virus: Toll-like Receptors and

   www.ncbi.nlm.nih.gov/pmc/articles/PMC9147118/

   See all results for this question

3. www.ncbi.nlm.nih.gov › pmc › articlesDengue virus and the host innate immune response - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 10, 2018 · The innate immune response to DENV is not well characterized nor are the exact roles of the NS proteins in evading the immune response. The main innate immune response is type I IFN and the main evasion mechanism of the virus is to target against the type I IFN response.

4. www.nature.com › articles › s41577/019/0123-xAdaptive immune responses to primary and secondary dengue ...

   www.nature.com › articles › s41577/019/0123-x

   Jan 24, 2019 · Abstract. Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the circulation of multiple serotypes, global expansion of the disease and recent gains in vaccination...

   • Author: Ashley L St John, Ashley L St John, Abhay P S Rathore

   • Publish Year: 2019

5. www.ncbi.nlm.nih.gov › pmc › articlesThe Interplay between Dengue Virus and the Human Innate ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 10, 2019 · However, DENV has evolved to interfere with the innate immune signalling at multiple levels, hence dampening antiviral responses and favouring viral replication and dissemination. This review elaborates on the interplay between DENV and the innate immune system.

   • Author: Nicolas Tremblay, Wesley Freppel, Aïssatou Aïcha Sow, Laurent Chatel-Chaix
   • DOI: 10.3390/vaccines7040145

   • Publish Year: 2019
   • Publication: Vaccines (Basel). 2019 Dec; 7(4): 145.

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7. www.nature.com › scitable › contentImmune response to dengue infection | Learn Science at Scitable

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   When someone is infected with dengue, the body's innate and adaptive immune responses work together to fight the virus. B cells from the immune system produce antibodies that recognize and...

8. www.nature.com › scitable › topicpageHost Response to the Dengue Virus | Learn Science at Scitable

   www.nature.com › scitable › topicpage

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   The innate immune response rapidly recognizes and responds to pathogens, but it does not provide a person with long-term immunity against an invading pathogen. The second part of the immune...

9. www.frontiersin.org › journals › immunologyFrontiers | How Dengue Virus Circumvents Innate Immunity

   www.frontiersin.org › journals › immunology

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   Dec 3, 2018 · DENV passively escapes from innate immunity surveillance and also actively subverts the innate immune system at multiple steps. DENV targets both RNA-triggered RLR–mitochondrial antiviral signaling protein (RLR–MAVS) and DNA-triggered cGAS–STING signaling to reduce IFN production in infected cells.