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      • For example, amiodarone, diltiazem and saw palmetto (CYP3A4 and/or P-glycoprotein inhibitors) inhibit the metabolism of rivaroxaban, and apixaban and increase their serum levels. 2,3 Other combinations which have shown to enhance bleeding risk include the concomitant use of apixaban and selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors. 16 Antiplatelets such as aspirin, clopidogrel, and ticagrelor when used with DOACs increase the bleeding risk due to an... › latest-in-cardiology › articles
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  2. While the majority of studies document the efficacy and safety of saw palmetto, some studies document the adverse side effects, including increased risk of bleeding. There are no reports in the literature about increased prothombin time (PT), partial thromboplastin time (PTT) or international normalized ratio (INR) while using saw palmetto.

    • Salvador Villanueva, Jenniffer González
    • 2009
    • What Is Saw Palmetto?
    • Saw Palmetto Side Effects
    • Warnings
    • Before Taking This Medicine
    • How Should I Take Saw Palmetto?
    • What Happens If I Miss A dose?
    • What Should I Avoid While Taking Saw Palmetto?
    • What Other Drugs Will Affect Saw Palmetto?
    • Further Information

    Saw palmetto comes from a palm-like plant that grows in the southeast United States. The berries of this plant are used to make the capsule form of saw palmetto. Saw palmetto is also known as American Dwarf Palm Tree, Baies du Palmier Scie, Cabbage Palm, Chou Palmiste, Ju-Zhong, Palma Enana Americana, Palmier Nain, Palmier Scie, Sabal, Serenoa, and...

    Get emergency medical help if you have signs of an allergic reaction:hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Although not all side effects are known, saw palmetto is thought to be likely safe for most people. Stop using saw palmetto and call your healthcare provider at once if you have: 1. easy bruising or bleed...

    Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

    Before using saw palmetto, talk to your healthcare provider. You may not be able to use saw palmetto if you have certain medical conditions., such as: 1. a bleeding or blood clotting disorder (such as hemophilia); 2. liver disease; or 3. a pancreas disorder. Saw palmetto is a hormone and is not likely to be safe to use during pregnancy. Do not use ...

    When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. If you choose to use saw palmetto, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this ...

    Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra saw palmetto to make up the missed dose.

    Avoid using saw palmetto together with other herbal/health supplements that can also affect blood-clotting. This includes angelica (dong quai), capsicum, clove, danshen, garlic, ginger, ginkgo, horse chestnut, panax ginseng, poplar, red clover, turmeric, vitamin E, and willow.

    Do not take saw palmetto without medical advice if you are using any of the following medications: 1. birth control pills or hormone replacement therapy; 2. medicine to prevent blood clots--clopidogrel, dalteparin, enoxaparin, rivaroxaban, warfarin, Coumadin, Jantoven, and others; or 3. an NSAID (nonsteroidal anti-inflammatory drug--aspirin, ibupro...

    Consult with a licensed healthcare professional before using any herbal/health supplement. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supp...

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  3. Jul 26, 2021 · Lifelong treatment with antiplatelet drugs is recommended following a transient ischemic attack or ischemic stroke. Bleeding complications may offset the benefit of antiplatelet drugs in patients at increased risk of bleeding and low risk of recurrent ischemic events.

    • Nina A. Hilkens, Nina A. Hilkens, Ale Algra, Hans Christoph Diener, Philip M. Bath, László Csiba, We...
    • 2021
  4. Jan 8, 2019 · On the other hand, concomitant use of warfarin resulted in increased risk of bleeding, based on observation of a case involving a 53-year old-man who underwent surgical procedures to remove brain tumor after taking saw palmetto . In the absence of coumarin compounds in saw palmetto and lack of demonstrable antiplatelet activity, the mechanism ...

    • Worku Abebe
    • Worku Abebe
    • 2019
    • 10.1007/s13167-018-0158-2
  5. Jul 27, 2015 · Bleeding risks of garlic, ginkgo, ginseng, green tea, saw palmetto, St John’s wort, and fish oil are reported. Cardiovascular instability was observed with ephedra, ginseng, and kava. Pharmacodynamic and pharmacokinetic interactions between dietary supplements and drugs used in the perioperative period are discussed. Conclusions

    • Chong-Zhi Wang, Jonathan Moss, Chun-Su Yuan
    • 2015
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