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A drug rash, sometimes called a drug eruption, is a reaction your skin can have to certain drugs. Almost any drug can cause a rash. But antibiotics (especially penicillins and sulfa drugs), NSAIDs ...
Picture of Fixed Drug Eruption The photo depicts a fixed drug eruption appearing on the arm of a child. The lesion is a large, red-purple plaque.
View an Illustration of Fixed Drug Eruption and learn more about Papules, Scales, Plaques and Eruptions.
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Bullous drug eruptions (immunobullous disease is important to recognise, as drug withdrawal leads to clearance) Drug-induced lupus erythematosus. A drug eruption is sometimes, unnecessarily, called a cutaneous drug eruption. Drugs can also cause: Drug-induced skin pigmentation
Fixed drug eruption is generally a benign self-resolving eruption that recurs on re-exposure, leaving post-inflammatory hyperpigmentation. Subsequent flares can be more severe. Generalised bullous fixed drug eruption can be life-threatening, and has been reported to have a 20% mortality rate. Appendix: list of some causes of fixed drug eruption
How is a lichenoid drug eruption diagnosed? The diagnosis may be suspected from the unusual clinical features and a skin biopsy then taken. The pathological features of a lichenoid drug eruption may be difficult to distinguish from idiopathic lichen planus, but the diagnosis of lichenoid drug eruptions may be suggested by the types and distribution of inflammatory cells as well as other changes.
Drug-induced phototoxic or photoallergic reaction – Look for eruptions on sun-exposed areas. Exanthematous drug eruption – Look for morbilliform morphology of lesions without xerosis, scale, or vesicle formation. Chronic eczematous eruptions of the aged; Lichenoid drug eruption – Look for violaceous, scaling papules and plaques.