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- Morbilliform drug eruption is a form of allergic reaction. It is mediated by cytotoxic T-cells and classified as a Type IV immune reaction. The target of attack may be drug, a metabolite of the drug, or a protein bonded to the drug. Inflammation follows the release of cytokines and other effector immune cells.
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What causes morbilliform drug eruption? Morbilliform drug eruption is a form of allergic reaction. It is mediated by cytotoxic T-cells and classified as a Type IV immune reaction. The target of attack may be drug, a metabolite of the drug, or a protein bonded to the drug.
There are several causes of drug eruptions: True allergy: this is due to an immunological mechanism. Immediate reactions occur within an hour of exposure to the drug and are mediated by IgE antibodies ( urticaria, anaphylaxis ). Delayed reactions occur between 6 hours and several weeks of first exposure to the drug.
Jan 12, 2023 · It is characterized by a disseminated, and occasionally generalized, symmetric eruption of erythematous macules and/or papules ( picture 1A-B) that occur approximately one to two weeks after initiating treatment with the causative drug or, in previously sensitized individuals, as early as 6 to 12 hours and up to three days after initiating treat...
Apr 10, 2023 · The rash develops one day to three weeks after the offending drug is first given, although the timing can differ if previously sensitized. The eruptions appear clinically as polymorphic maculopapular lesions with no mucosal involvement, resembling a viral exanthem.
- Daifallah M. Al Aboud, Wissem Hafsi
- 2023/04/10
- 2019
Jan 31, 2011 · Drug eruptions are among the most common diseases of the skin. In most instances, they are diagnosed readily on the basis of clinical picture and clinical history, namely, a symmetrical, widespread maculopapular eruption following recent intake of a newly prescribed drug.
- Wolfgang Weyers, Dieter Metze
- 10.5826/dpc.0101a09
- 2001
- 2011/01
Feb 22, 2023 · Exanthematous drug eruptions; Lichenoid drug eruption (drug-induced lichen planus) Exfoliative dermatitis/erythroderma; Urticaria/angioedema; Anaphylaxis; Cutaneous small vessel vasculitis; UNCOMMON DRUG REACTION PATTERNS. Severe cutaneous reactions - Stevens-Johnson syndrome/toxic epidermal necrolysis - Drug reaction with eosinophilia and ...
Mucous membrane erosions. Blisters. Nikolsky sign. Confluent erythema. Angioedema and tongue swelling. Palpable purpura. Skin necrosis. Lymphadenopathy. High fever, dyspnea, or hypotension. It is...
