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Jan 12, 2023 · Exanthematous (maculopapular) drug eruption, also called morbilliform (measles-like) drug-induced exanthem, is the most common drug hypersensitivity reaction [ 1,2 ]. It is characterized by a disseminated, and occasionally generalized, symmetric eruption of erythematous macules and/or papules ( picture 1A-B) that occur approximately one to two ...
- Rosamaria Corona, Md, DSc
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- Bigby M. Rates of Cutaneous Reactions to Drugs. Arch Dermatol 2001; 137:765
LIMITATIONS Such an observational study with retrospective...
- Seitz Cs, Rose C, Kerstan A, Trautmann A. Drug-induced Exanthems: Correlation of Allergy Testing With Histologic Diagnosis. J Am Acad Dermatol 2013; 69:721
Drug-induced exanthems: correlation of allergy testing with...
- Drug eruptions
Classic and less common clinical presentations of cutaneous...
- Fixed drug eruption
INTRODUCTION. Fixed drug eruption (FDE) is a distinctive...
- Rosamaria Corona, Md, DSc
Jul 7, 2022 · Treatment of a drug eruption depends on the specific type of reaction. Therapy for exanthematous drug eruptions is supportive in nature. First-generation antihistamines are used 24 h/d. Mild topical steroids (eg, hydrocortisone, desonide) and moisturizing lotions are also used, especially during the late desquamative phase.
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- What Is A Drug Eruption?
- Who Gets Drug eruptions?
- What Causes Drug eruptions?
- What Are The Clinical Features of Drug eruptions?
- Complications of Drug Eruptions
- How Are Drug Eruptions Diagnosed?
- What Is The Treatment For Drug eruptions?
- How Can Drug Eruptions Be Prevented?
- What Is The Outlook For Patients with Drug eruptions?
Acute or subacute adverse cutaneous reactions to a drug or medicine include drug eruptions. There are many types of drug eruption, which range from a clinically mild and unnoticed rash to a severe cutaneous adverse reaction (SCAR)that may be life-threatening. The most common drug eruptions are: 1. Morbilliform or exanthematousdrug eruption 2. Urtic...
On average, about 2% of prescriptions for a new medication lead to a drug eruption. 1. Allergic reactionsto some drugs are more common in females than in males. 2. There are genetic factors that predispose people to drug eruptions. These may include differences in drug metabolism. 3. Underlying viral infectionsand diseases can influence reactions. ...
There are several causes of drug eruptions: 1. True allergy: this is due to an immunological mechanism 1.1. Immediate reactions occur within an hour of exposure to the drug and are mediated by IgE antibodies (urticaria, anaphylaxis). 1.2. Delayed reactions occur between 6 hours and several weeks of first exposure to the drug. They may be mediated b...
Additional systemic symptoms accompanying drug eruption may include: 1. Fever 2. Malaise 3. Other organ involvement (in SCAR).
Incorrect attribution of drug eruption can deprive the patient of a useful medication, or lead to recurrencewhen the drug is taken at a later date. Patients with SCAR may die from it. SJS/TEN can cause permanent scarring leading to blindness and deformity.
A careful history, skin and general physical examination are necessary to diagnose a drug eruption and to assess its severity. 1. Determine any previous exposure to the medication(s) under suspicion. 2. Review the medical record to determine the relationship between onset of symptoms and commencing medication(s). 3. Some medications (such as antibi...
The main thing is to identify and stop the responsible drug as soon as possible. The use of systemic steroids for drug eruptions, for example, prednisone, is controversial. They are unnecessary if the rash is mild. Get advice from a specialist immunologist or dermatologistif the rash is severe. 1. Topical corticosteroids (such as betamethasone crea...
As most serious drug eruptions are due to antibiotics, their use should be limited and underlying conditions should be treated in other ways whenever possible. For example, acne can be treated with isotretinoin. Clinicians should ask their patients about previous drug allergieswhen prescribing a new medicine. Drug allergies should be recorded in th...
Some patients can tolerate re-exposure to a medication that was thought to cause an earlier drug eruption. Reasons for this may include: 1. The drug was not responsible for the original symptoms. 2. Drug sensitivity has been lost over time. 3. The reaction may have depended on an underlying illness that has resolved. For those with confirmed drug a...
A drug rash or eruption is a type of drug reaction involving your skin. We'll go over how to identify the different types and which ones require medical treatment.
Drugs can cause multiple skin eruptions and reactions. The most serious of these are discussed elsewhere in THE MANUAL and include Stevens-Johnson syndrome and toxic epidermal necrolysis, hypersensitivity syndrome, serum sickness, exfoliative dermatitis, angioedema, anaphylaxis, and drug-induced vasculitis. Drugs can also be implicated in hair ...
