- Treatment of a drug eruption depends on the specific type of reaction. Therapy for exanthematous drug eruptions is supportive in nature. First-generation antihistamines are used 24 h/d. Mild topical steroids (eg, hydrocortisone, desonide) and moisturizing lotions are also used, especially during the late desquamative phase.
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Oct 14, 2020 · Treatment of a drug eruption depends on the specific type of reaction. Therapy for exanthematous drug eruptions is supportive in nature. First-generation antihistamines are used 24 h/d. Mild...
A drug rash or eruption is a type of drug reaction involving your skin. We'll go over how to identify the different types and which ones require medical treatment.
The suspected immunologic orgin of drug eruptions prompted the use of corticosteroids, immunosuppressive drugs, and anti-cytokines. Systemic corticosteroids are useful in "hypersensitivity syndrome" when visceral lesions depend on infiltration by activated cosinophils. Systemic corticosteroids were shown to be deleterious in cases of advanced TEN.
- Jean-Claude Roujeau
Treatment includes identifying and withdrawing the offending agent as soon as possible. A biopsy may be helpful in establishing a diagnosis of a drug reaction. For mild drug eruptions, treatment is supportive with anti-histamines, topical steroids, and moisturizing lotions. Severe reactions warrant admission to the hospital for a more thorough ...
If anaphylaxis occurs, treatment is with aqueous epinephrine (1:1000) 0.2 mL subcutaneously or IM, parenteral antihistamines, and with the slower-acting but more persistent soluble hydrocortisone 100 mg IV, which may be followed by an oral corticosteroid for a short period.Type of ReactionDescription and CommentsTypical Causative AgentsAcneiform eruptionsResemble acne but lack comedones and usually begin suddenlyCorticosteroids, epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MEK) inhibitors, iodides, bromides, hydantoins, androgenic steroids, lithium, isoniazid, phenytoin, phenobarbital, vitamins B2, B6, and B12Acute generalized exanthematous pustulosisRapidly appearing and spreading pustular eruptionMost commonly antibiotics, including macrolides and penicillinsBlistering eruptionsAppear with widespread vesicles and bullaePemphigus: Penicillin, penicillamine, and other thiol compounds Bullous pemphigoid: Penicillamine and furosemide (most common) Linear immunoglobulin A (IgA) bullous dermatosis: Vancomycin (most common)Cutaneous necrosisAppears as demarcated, painful, erythematous or hemorrhagic lesions progressing to hemorrhagic bullae and full-thickness skin necrosis with eschar formationWarfarin, heparin, barbiturates, epinephrine, norepinephrine, vasopressin, levamisole (contaminant in street preparations of cocaine)
Other treatments that may be helpful include: Oral antihistamine pills, such as diphenhydramine, hydroxyzine, loratadine, cetirizine, fexofenadine, or desloratadine, for itching. Topical corticosteroid (cortisone) creams or lotions for red, inflamed skin. Topical antibiotic ointments for open sores.
Nov 01, 2003 · Additional therapy for drug hypersensitivity reactions is largely supportive and symptomatic (Table 6). Systemic corticosteroids may speed recovery in severe cases of drug hypersensitivity. Topical...
- Marc A Riedl, Adrian M Casillas
Drug rashes are the body's reaction to a certain medicine. The type of rash that happens depends on the medicine causing it and your response. Medicines have been linked to every type of rash, ranging from mild to life-threatening. The timing of the rash can also vary. It may appear right away or a ...Type of rashSymptomsCauseAcnePimples and red areas that appear most often on the face, shoulders, and chestAnabolic steroids, corticosteroids, bromides, iodides, and phenytoinExfoliative dermatitisRed, scaly skin that may thicken and peel and involve the entire bodyAntibiotics that contain sulfa, barbiturates, isoniazid, penicillins, and phenytoinFixed drug eruptionA dark red or purple rash that reacts at the same siteAntibiotics and phenolphthalein (found in certain laxatives)HivesRaised red bumpsAspirin, certain medicine dyes, penicillins, and many other medicines
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