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      • Treatment of a drug eruption depends on the specific type of reaction. Therapy for exanthematous drug eruptions is supportive in nature. First-generation antihistamines are used 24 h/d. Mild topical steroids (eg, hydrocortisone, desonide) and moisturizing lotions are also used, especially during the late desquamative phase.
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  2. Drug Eruptions Treatment & Management: Medical Care › article › 1049474-treatment

    Oct 14, 2020 · Treatment of a drug eruption depends on the specific type of reaction. Therapy for exanthematous drug eruptions is supportive in nature. First-generation antihistamines are used 24 h/d. Mild...

  3. Drug Rash and Eruption: Symptoms, Pictures, Causes, and Treatment › health › drug-rash

    A drug rash or eruption is a type of drug reaction involving your skin. We'll go over how to identify the different types and which ones require medical treatment.

  4. Treatment of severe drug eruptions - PubMed › 10635613

    The suspected immunologic orgin of drug eruptions prompted the use of corticosteroids, immunosuppressive drugs, and anti-cytokines. Systemic corticosteroids are useful in "hypersensitivity syndrome" when visceral lesions depend on infiltration by activated cosinophils. Systemic corticosteroids were shown to be deleterious in cases of advanced TEN.

    • Jean-Claude Roujeau
    • 114
    • 1999
  5. Treatment includes identifying and withdrawing the offending agent as soon as possible. A biopsy may be helpful in establishing a diagnosis of a drug reaction. For mild drug eruptions, treatment is supportive with anti-histamines, topical steroids, and moisturizing lotions. Severe reactions warrant admission to the hospital for a more thorough ...

  6. Drug Eruptions and Reactions - Dermatologic Disorders - Merck ... › professional › dermatologic

    If anaphylaxis occurs, treatment is with aqueous epinephrine (1:1000) 0.2 mL subcutaneously or IM, parenteral antihistamines, and with the slower-acting but more persistent soluble hydrocortisone 100 mg IV, which may be followed by an oral corticosteroid for a short period.

    Type of Reaction
    Description and Comments
    Typical Causative Agents
    Acneiform eruptions
    Resemble acne but lack comedones and usually begin suddenly
    Corticosteroids, epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MEK) inhibitors, iodides, bromides, hydantoins, androgenic steroids, lithium, isoniazid, phenytoin, phenobarbital, vitamins B2, B6, and B12
    Acute generalized exanthematous pustulosis
    Rapidly appearing and spreading pustular eruption
    Most commonly antibiotics, including macrolides and penicillins
    Blistering eruptions
    Appear with widespread vesicles and bullae
    Pemphigus: Penicillin, penicillamine, and other thiol compounds Bullous pemphigoid: Penicillamine and furosemide (most common) Linear immunoglobulin A (IgA) bullous dermatosis: Vancomycin (most common)
    Cutaneous necrosis
    Appears as demarcated, painful, erythematous or hemorrhagic lesions progressing to hemorrhagic bullae and full-thickness skin necrosis with eschar formation
    Warfarin, heparin, barbiturates, epinephrine, norepinephrine, vasopressin, levamisole (contaminant in street preparations of cocaine)
  7. Drug Eruption in Adults: Condition, Treatments, and Pictures ... › adult › drug-eruption

    Other treatments that may be helpful include: Oral antihistamine pills, such as diphenhydramine, hydroxyzine, loratadine, cetirizine, fexofenadine, or desloratadine, for itching. Topical corticosteroid (cortisone) creams or lotions for red, inflamed skin. Topical antibiotic ointments for open sores.

  8. Nov 01, 2003 · Additional therapy for drug hypersensitivity reactions is largely supportive and symptomatic (Table 6). Systemic corticosteroids may speed recovery in severe cases of drug hypersensitivity. Topical...

    • Marc A Riedl, Adrian M Casillas
    • 254
    • 2003
  9. Drug Rashes | Johns Hopkins Medicine › drug-rashes

    Drug rashes are the body's reaction to a certain medicine. The type of rash that happens depends on the medicine causing it and your response. Medicines have been linked to every type of rash, ranging from mild to life-threatening. The timing of the rash can also vary. It may appear right away or a ...

    Type of rash
    Pimples and red areas that appear most often on the face, shoulders, and chest
    Anabolic steroids, corticosteroids, bromides, iodides, and phenytoin
    Exfoliative dermatitis
    Red, scaly skin that may thicken and peel and involve the entire body
    Antibiotics that contain sulfa, barbiturates, isoniazid, penicillins, and phenytoin
    Fixed drug eruption
    A dark red or purple rash that reacts at the same site
    Antibiotics and phenolphthalein (found in certain laxatives)
    Raised red bumps
    Aspirin, certain medicine dyes, penicillins, and many other medicines
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