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  1. Jul 7, 2022 · Therapy for most drug eruptions is mainly supportive in nature. Morbilliform eruptions are treated with oral antihistamines and topical steroids. IVIG is currently the most common agent used to treat TEN. Cyclosporine may also have a role in the treatment of TEN.

  2. Non-immunological drug eruptions. These may be due to idiosyncratic reaction, hereditary enzyme deficiency, dose dependent cumulation, irritancy or toxicity. Examples include: Eczema craquelé aggravated by diuretics. Cutaneous atrophy, striae and telangiectasia due to topical or systemic steroids.

  3. Jan 30, 2020 · A fixed drug eruption (FDE) is a relatively common reaction associated with more than 100 medications. It is defined as a same-site recurrence with exposure to a particular medication. The primary approach and treatment for all types of FDEs are to identify and remove the causative agent, often accomplished by a thorough history of medication and other chemical exposures, and possibly prior ...

  4. Apr 8, 2024 · INTRODUCTION. Fixed drug eruption (FDE) is a distinctive type of cutaneous drug reaction that characteristically recurs in the same locations upon re-exposure to the offending drug. Acute FDE usually presents with a single or a small number of dusky red or violaceous plaques that resolve leaving postinflammatory hyperpigmentation ( picture 1A-C ).

  5. Aug 29, 2020 · AskMayoExpert. Drug eruption. Mayo Clinic; 2020. AskMayoExpert. Nonimmunoglobulin e-mediated (non-IgE) drug sensitivity. Mayo Clinic; 2019. Seminario-Vidal L., et al. Society of dermatology hospitalists supportive care guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults.

  6. Mar 13, 2019 · Drug eruptions have been reported to occur in 2 to 3% of hospitalized patients. MDE was noted to be the most common drug eruption in these patients in a systematic review in 2001. The rates varied between 73% and 91% of all drug eruptions. There is a higher risk of all drug eruptions in the HIV-positive population and in women.

  7. Apr 10, 2023 · Exanthematous eruptions, also described as morbilliform or ery­thematous maculopapular eruptions, are the most common type of drug reaction, accounting for approximately 40% of all reactions. The rash develops one day to three weeks after the offending drug is first given, although the timing can differ if previously sensitized.

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