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Edwin Klebs introduced the paraffin-embedding methodology in 1869. 18 However, at that time, ... Charleston, SC, USA. Yuehuei H. An MD (Associate Professor, ...
- Yuehuei H. An, Patricia L. Moreira, Qian K. Kang, Helen E. Gruber
- 2003
Original Article from The New England Journal of Medicine — Edwin Klebs, M.D.
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- Medical Studies in Königsberg and Würzburg
- Assistant of Rudolf Virchow
- Contributions to Pathological Anatomy
- Klebs’ Bacteriological Tests
- Further Research
- The Malaria Disaster
- Later Life
Edwin Klebs was born in Königsberg, Province of Prussia. Ignoring the family tradition to study law, he turn towards medicine and studied for five semesters at the University of Königsberg with embryologist and anatomist Martin Rathke, physician and physicist Hermann von Helmholtz, and others. In 1855 at age twentyone, he went to Würzburg to study ...
Klebs was an assistant to Virchow at the Charité in Berlin from 1861 until 1866, when he became a professor of pathology at the University of Bern in Switzerland. He served as a military physician for the Prussian Army in 1870 during the Franco-Prussian War. Klebs taught at Würzburg from 1872 to 1873, at Prague from 1873 to 1882, and at Zürich from...
Klebs’ contributions to pathological anatomy and physiology included the first experimental production of valvular disease of the heart. He preceded Robert Kochin studying the bacteriology of traumatic infections, and in 1876 he succeeded in producing endocarditis by mechanical means combined with general infection.
Klebs identified four “Grundversuche” (fundamental tests) that provided a basis for his own research strategy, as well as general bacteriological research. According to Klebs, the bacteriological tests consist of the following postulates: 1. all bacteria are pathological 2. bacteria never occur spontaneously 3. every disease is caused only by bacte...
From researches on tuberculosis he was able to produce bovine infection by means of milk thereby establishing the bovine origin of the disease. In 1878 he successfully transmitted syphilis to monkeys, antedating the experiments of Élie Metchnikoff and Émile Roux by 25 years. In 1883 Klebs successfully identified the bacterium Corynebacterium dipht...
Klebs made several mistakes about the causes of infectious diseases. He thought that malaria was caused by a bacterium, which he and Corrado Tommasi-Crudeli claimed to have isolated from the waters of the Pontine Marshes in Roman Campagna in 1879. They named it Bacillus malariae and believed it was the cause of malaria because infected rabbits deve...
From 1896 to 1900 Klebs taught at Rush Medical College in Chicago, United States. From 1905 to 1910 he was a private researcher in Berlin, after which he returned to Switzerland, living with his oldest son in Lausanne. Klebs died in Bern in 1913, aged 79. The History of Microbiology in English – Microbiology with Sumi, References and Further Readin...
IN a centennial note published in the New England Journal of Medicine of July 11, Dr. Leona Baum-gartner, of Cornell University Medical College, New York, claims that Edwin Klebs, who was born on ...
germ theory. Edwin Klebs (born Feb. 6, 1834, Königsberg, Prussia [now Kaliningrad, Russia]—died Oct. 23, 1913, Bern, Switz.) was a German physician and bacteriologist noted for his work on the bacterial theory of infection. With Friedrich August Johannes Löffler in 1884, he discovered the diphtheria bacillus, known as the Klebs-Löffler ...
EDWIN KLEBS (1834-1913) PERIPATETIC BACTERIOLOGIST. Theodor Albrecht Edwin Klebs, a native of Königsberg and contemporary of Pasteur and Koch, had an unrivaled experience in pathological anatomy and gained scientific rewards comparable to other great European bacteriologists. 1 Klebs studied medicine in Königsberg with Rathke, Helmholtz, and ...
