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Endolimax is a genus of amoebozoa [1] that are found in the intestines of various animals, including the species E. nana found in humans. Originally thought to be non-pathogenic, studies suggest it can cause intermittent or chronic diarrhea.

Endolimax nana (Fig. 4-1) is the smallest of the intestine-dwelling amoebae infecting humans, its trophozoite averaging only 8 μm in diameter (range, 6-15 μm). The trophozoite lives in the host’s colon and is generally considered to be nonpathogenic.

What you need to know... Last Reviewed: June 2, 2023 Source: Global Health, Division of Parasitic Diseases and Malaria Education and information about Nonpathogenic (Harmless) Intestinal Protozoa including frequently asked questions, biology and life cycle information and publications.

Abstract. Of the so-called nonpathogenic intestinal protozoa, Endolimax nana belongs to the ones least well described. Most data on E. nana have emerged from general surveys of intestinal parasites in selected cohorts and mostly in the absence of any particular focus on Endolimax.

Life cycle of nonpathogenic intestinal amebae include several Entamoeba species (Entamoeba coli, Entamoeba hartmanni, and Entamoeba polecki), Endolimax nana, and Iodamoeba buetschlii (=I. bütschlii). Used with permission from CDC Public Health Image Library