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One other key piece of information related to the structure of DNA came from Austrian biochemist Erwin Chargaff. Chargaff analyzed the DNA of different species, determining its composition of A, T, C, and G bases. He made several key observations: A, T, C, and G were not found in equal quantities (as some models at the time would have predicted)
In heredity: Structure and composition of DNA. …it was found by biochemist Erwin Chargaff that the amount of A is always equal to T, and the amount of G is always equal to C. Read More.
His two main discoveries, (i) that in any double-stranded DNA the number of guanine units equals thenumber of cytosine units and the number of adenine units equals the number ofthymine units and (ii) that the composition of DNA varies from one species toanother, are now known as Chargaff's Rules.
Jun 30, 2002 · Erwin Chargaff, whose research into the chemical composition of DNA helped lay the groundwork for James Watson and Francis Crick's discovery of its double-helix structure -- the pivotal finding...
Jul 2, 2002 · Erwin Chargaff, who has died aged 96, was one of the giants of the world of biochemistry. He did pioneering work in several fields; hence, his absence from the roll of Nobel prizewinners...
Address: 105 South Fifth Street, Philadelphia, PA 19106-3386. Size: 113 boxes, 56 linear feet. Finding Aid: http://www.amphilsoc.org/mole/view?docId=ead/Mss.B.C37-ead.xml;query=Erwin%20Chargaff;brand=default. Phone: 215-440-3400. Email: manuscripts@amphilsoc.org Web: http://www.amphilsoc.org/library. Pictures and Illustrations.
Erwin Chargaff was one of a handful of scientists who expanded on Levene's work by uncovering additional details of the structure of DNA, thus further paving the way for Watson and Crick.
