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Erythromycin's elimination half-life ranges between 1.5 and 2.0 hours and is between 5 and 6 hours in patients with end-stage renal disease. Erythromycin levels peak in the serum 4 hours after dosing; ethylsuccinate peaks 0.5–2.5 hours after dosing, but can be delayed if digested with food.
Dec 31, 2015 · Absorption. Orally administered erythromycin is readily absorbed. Food intake does not appear to exert effects on serum concentrations of erythromycin. 21 Some interindividual variation exists in terms of erythromycin absorption, which may impact absorption to varying degrees. 21 The Cmax of erythromycin is 1.8 mcg/L 15 and the Tmax is 1.2 hours. 19 The serum AUC of erythromycin after the ...
Jul 2, 2023 · Erythromycin has traditionally been used for various respiratory infections (i.e., community-acquired pneumonia, Legionnaires disease), prophylaxis of neonatal conjunctivitis, and chlamydia. It is also FDA-approved for treating skin infections, intestinal amebiasis, rheumatic fever, prophylaxis, syphilis, and pelvic inflammatory disease (PID). In addition, if mixed with tretinoin cream or ...
- 2023/07/02
- General
- Pediatric Dosing
- Special Populations
- Contraindications
- Adverse Reactions
- Pharmacology
- Antibiotic Sensitivities
Type: MacrolideDosage Forms: PO, IV, topicalCommon Trade Names:Mild-moderate infections: 30-50 mg/kg/day PO divided q6-8hrSevere infection: 60-100 mg/kg/day PO divided q6-8hrRenal Dosing: No adjustmentHepatic Dosing: Use cautionAllergy to class/drugQT prolongationSerious
1. Torsades, ventricular dysrhythmias 2. Pseudomembranous colitis 3. Hypertrophic pyloric stenosis 4. Seizures
Common
1. nausea/vomiting 2. diarrhea 3. urticaria 4. transaminitis 5. urticarial rash
Half-life: 2 hoursMetabolism: LiverExcretion: Bile/RenalMechanism of Action: Binds to 50S ribosomal unit → inhibiting protein synthesisKey
1. Ssusceptible/sensitive (usually) 2. Iintermediate (variably susceptible/resistant) 3. Rresistant (or not effective clinically) 4. S+synergistic with cell wall antibiotics 5. Usensitive for UTI only (non systemic infection) 6. X1no data 7. X2active in vitro, but not used clinically 8. X3active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis 9. X4active in vitro, but not clinically effective for strep pneumonia
Mar 21, 2024 · Common erythromycin side effects may include: severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose); liver problems; or. abnormal liver function tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
- (60)
- Medical Doctor
- You should not use erythromycin if you are allergic to it.Some medicines can cause unwanted or dangerous effects when used with erythromycin. Your...
- Take erythromycin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruct...
- Usual Adult Dose of Erythromycin for Campylobacter Gastroenteritis:Mild to moderate infection: 250 to 500 mg (base, estolate, stearate) or 400 to 8...
- Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
- Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor be...
- Get emergency medical help if you have signs of an allergic reaction to erythromycin (hives, difficult breathing, swelling in your face or throat)...
- Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may in...
Excerpt. Erythromycin has traditionally been used for various respiratory infections (i.e., community-acquired pneumonia, Legionnaires disease), prophylaxis of neonatal conjunctivitis, and chlamydia. It is also FDA-approved for treating skin infections, intestinal amebiasis, rheumatic fever, prophylaxis, syphilis, and pelvic inflammatory ...
Erythromycin's elimination half-life is 1.5 hours. The macrolide antibiotics erythromycin, clarithromycin, and roxithromycin have proven to be effective as long-term treatment for the idiopathic, Asian-prevalent lung disease diffuse panbronchiolitis (DPB) (Keicho and Kudoh 2002; Lopez-Boado and Rubin 2008).
