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Feb 24, 2023 · Within primary and secondary hemostasis, 3 coagulation pathways exist: intrinsic, extrinsic, and common. [1] [2] [3] [4] Pathways. The intrinsic pathway responds to spontaneous, internal damage of the vascular endothelium, whereas the extrinsic pathway becomes activated secondary to external trauma.
The extrinsic pathway, which normally is triggered by trauma. The intrinsic pathway, which begins in the bloodstream and is triggered by internal damage to the wall of the vessel. Both of these merge into a third pathway, referred to as the common pathway (see Figure 18.5.1 b ).
Although the traditional classification of the coagulation system into extrinsic and intrinsic pathway is still valid, the newer insights into coagulation provide more authentic description of the same.
The process is complex, but is initiated along two basic pathways: The extrinsic pathway, which normally is triggered by trauma. The intrinsic pathway, which begins in the bloodstream and is triggered by internal damage to the wall of the vessel. Both of these merge into a third pathway, referred to as the common pathway (see Figure 18.14b).
Sep 4, 2023 · Introduction. Blood is a necessary component of the human body, and the loss of this fluid may be life-threatening. Blood is generated via hematopoiesis and ultimately becomes the delivery method for oxygen to the tissues and cells. The human body protects against loss of blood through the clotting mechanism.
Jan 17, 2023 · The intrinsic pathway occurs when negatively charged molecule contact causes a cascade of factors that produce factor X. The extrinsic pathway occurs when tissue damage causes the release of tissue factor, creating a smaller cascade that produces factor X.
The thrombin converts fibrinogen to fibrin. With the exception of factor VII, all components of the extrinsic pathway are also components of the intrinsic pathway. The activity of the extrinsic pathway may be assessed in the laboratory using a simple test known as the prothrombin time.
