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   Can melanoma cause FAMMM syndrome?

   • FAMMM syndrome may also increase the risk of pancreatic cancer in addition to melanoma. FAMMM syndrome may be caused by genetic changes in the CDKN2A gene (in about 40% of cases) or CDK4 gene (in very rare cases). However, in many cases, the cause is unknown. Inheritance is autosomal dominant.

   Familial atypical multiple mole melanoma syndrome

   rarediseases.info.nih.gov/diseases/9281/familial-atypical-multiple-mole-melanoma-syndrome/

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   What is familial melanoma?

   • Familial melanoma is defined as a family in which either 2 first-degree relatives or 3 or more melanoma patients on the same side of the family (irrespective of degree of relationship) are diagnosed with melanoma [ 5 ]. In these families the pattern of heritability is consistent with an autosomal dominant inheritance with incomplete penetrance.

   Familial Melanoma: Diagnostic and Management Implications

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6368081/

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   Is fammms a malignancy?

   • It is known to be associated with carcinoma of pancreas and other malignancies involving gastrointestinal tract, breast, lung, larynx, and skin in the kindred. There is no published report of FAMMMS in dark-skinned individuals.

   Familial Atypical Multiple Mole Melanoma Syndrome in an Adult Indian

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4372964/

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2. rarediseases.info.nih.gov › diseases › 9281Familial atypical multiple mole melanoma syndrome

   rarediseases.info.nih.gov › diseases › 9281

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   Summary. Familial atypical multiple mole melanoma syndrome (FAMMM syndrome) is an inherited condition characterized by the presence of multiple moles. Atypical moles, also called dysplastic nevi, are benign but are associated with an increased risk of melanoma.

   • Familial Melanoma: Diagnostic and Management Implications

     An estimated 5%–10% of all cutaneous melanoma cases occur in...

   • Familial Atypical Multiple Mole Melanoma Syndrome in an Adult ...

     Familial atypical multiple mole melanoma syndrome (FAMMMS)...

3. rarediseases.oscar.ncsu.edu › disease › familialAbout: Familial atypical multiple mole melanoma syndrome

   rarediseases.oscar.ncsu.edu › disease › familial

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   Definition. Orphanet. Familial atypical multiple mole melanoma (FAMMM) syndrome is an inherited genodermatosis characterized by the presence of multiple melanocytic nevi (often >50) and a family history of melanoma as well as, in a subset of patients, an increased risk of developing pancreatic cancer (see this term) and other malignancies.

4. www.jaad.org › article › S0190-9622(15)02108-8Hereditary melanoma: Update on syndromes and management

   www.jaad.org › article › S0190-9622(15)02108-8

   FAMMM. melanoma genetics. mixed cancer syndromes. General considerations for hereditary melanoma. Key point. •. Hereditary melanomas can appear as part of a familial melanoma syndrome or a mixed cancer syndrome. Cutaneous malignant melanoma (CMM) can be highly lethal if it is not detected and treated during its early stages.

   • Author: Efthymia Soura, Philip J. Eliades, Kristen Shannon, Alexander J. Stratigos, Hensin Tsao

   • Publish Year: 2016

5. rarediseases.oscar.ncsu.edu › disease › familialFamilial atypical multiple mole melanoma syndrome

   rarediseases.oscar.ncsu.edu › disease › familial

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   ← Back Familial atypical multiple mole melanoma syndrome Also known as: B-K mole syndrome, FAMM-PC syndrome, FAMMM syndrome, Familial Clark nevus syndrome, Familial atypical mole syndrome, Familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, Familial dysplastic nevus syndrome, Melanoma-pancreatic cancer syndrome

6. rarediseases.info.nih.gov › diseases › 9281Familial atypical multiple mole melanoma syndrome

   rarediseases.info.nih.gov › diseases › 9281

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   Learn about symptoms, cause, support, and research for a rare disease. Getting a Diagnosis. Take steps toward getting a diagnosis by working with your doctor, finding the right specialists, and coordinating medical care. Resources and Support.

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