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Fixed drug eruption is a delayed type IV hypersensitivity reaction to oral medications or other chemical agents. It causes red or violaceous patches, blisters or ulcers on the skin, and post-inflammatory hyperpigmentation. The web page explains the causes, clinical features, diagnosis and treatment of fixed drug eruption, with a list of possible causes and a differential diagnosis table.
Apr 8, 2024 · INTRODUCTION. Fixed drug eruption (FDE) is a distinctive type of cutaneous drug reaction that characteristically recurs in the same locations upon re-exposure to the offending drug. Acute FDE usually presents with a single or a small number of dusky red or violaceous plaques that resolve leaving postinflammatory hyperpigmentation ( picture 1A-C ).
Sep 1, 2021 · In some cases, there is an extensive eruption of bullae in addition to the characteristic patches of FDE, a condition referred to as generalized bullous fixed drug eruption (GBFDE) . One study of bullous FDEs presenting to a dermatology department in Tunisia over an 18-year period found that 44.4% of cases were localized and 55.6% of cases were ...
- Hannah J Anderson, Jason B Lee
- 10.3390/medicina57090925
- 2021
- Medicina (Kaunas). 2021 Sep; 57(9): 925.
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What is the treatment for fixed drug eruptions (FDEs)?
What is a fixed drug eruption érythémato-pigmentée fixe (FDE)?
What is fixed drug eruption (FDE)?
A fixed drug eruption (FDE) is a relatively common reaction associated with more than 100 medications. It is defined as a same-site recurrence with exposure to a particular medication. The primary approach and treatment for all types of FDEs are to identify and remove the causative agent, often accomplished by a thorough history of medication ...
- Shreya Patel, Ann M. John, Marc Zachary Handler, Robert A. Schwartz
- 2020
The main goal of treatment is to identify the causative agent and avoid it. Treatment for fixed drug eruptions (FDEs) otherwise is symptomatic. Systemic antihistamines and topical corticosteroids may be all that are required. In cases in which infection is suspected, antibiotics and proper wound care are advised.
Fixed drug eruption (FDE) is a well-defined, circular, hyperpigmenting plaque that recurs as one or a few lesions always in fixed locations upon ingestion of a drug. FDE commonly occurs on the genitals, lips, trunk, and hands. Although the lesions are distinctive, the diagnosis of FDE often is missed because it shares none of the characteristics of more common morbilliform drug rashes. The...
Feb 22, 2023 · Classic and less common clinical presentations of cutaneous adverse reactions to drugs will be reviewed here [ 1 ]. Drug allergy, noncutaneous hypersensitivity reactions, infusion reactions, and cutaneous adverse reactions to antineoplastic drugs are discussed elsewhere. Drug hypersensitivity reactions.
