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1. en.wikipedia.org › wiki › FibronectinFibronectin - Wikipedia

   en.wikipedia.org › wiki › Fibronectin

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   Fibronectin is a high- molecular weight (~500-~600 kDa) [5] glycoprotein of the extracellular matrix that binds to membrane -spanning receptor proteins called integrins. [6] Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans ).

   • Aliases: FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF

2. www.genecards.org › cgi-bin › carddispFN1 Gene - GeneCards | FINC Protein | FINC Antibody

   www.genecards.org › cgi-bin › carddisp

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   Apr 3, 2024 · FN1 (Fibronectin 1) is a Protein Coding gene. Diseases associated with FN1 include Spondylometaphyseal Dysplasia, Corner Fracture Type and Glomerulopathy With Fibronectin Deposits 2. Among its related pathways are Signaling downstream of RAS mutants and Integrin Pathway.

3. www.ncbi.nlm.nih.gov › pmc › articlesFN1 is a prognostic biomarker and correlated with immune ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Aug 23, 2022 · Fibronectin 1 (FN1) is an important ECM glycoprotein with several alternatively spliced variants ( 6 ). It has been shown to be involved in cell proliferation and migration and through integrin transmembrane receptors in ECM changes that occur during physiological and pathological processes ( 7, 8 ).

   • DOI: 10.3389/fonc.2022.918719
   • Published: 2022

   • Publication: Front Oncol. 2022; 12: 918719.

4. www.nature.com › articles › s41374/020/0451-2Fibronectin 1 activates WNT/β-catenin signaling to induce ...

   www.nature.com › articles › s41374/020/0451-2

   Jun 19, 2020 · Here we report that fibronectin 1 (FN-1) promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts. With isobaric tags for...

   • Author: Chengliang Yang, Chong Wang, Jing Zhou, Qingyang Liang, Feng He, Feng Li, Ye Li, Jinzhong Chen, Fan ...

   • Publish Year: 2020

5. www.ncbi.nlm.nih.gov › gene › 23352335 - Gene ResultFN1 fibronectin 1 [ (human)]

   www.ncbi.nlm.nih.gov › gene › 2335

   Apr 30, 2024 · FN1 mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the FN1 3'-UTR-let-7i-5p-THBS1 axis. RNA-binding protein-regulated fibronectin is essential for EGFR-activated metastasis of head and neck squamous cell carcinoma.

6. People also ask

   What are the coexpressed genes of fn1?

   • GO term annotation showed that the coexpressed genes of FN1 join mainly in extracellular structure organization, collagen metabolic process, integrin-mediated signaling pathway, substrate-dependent cell migration, artery development, peptide cross-linking, muscle cell migration, etc. ( Figure 3F ).

   FN1 is a prognostic biomarker and correlated with immune infiltrates in

   www.ncbi.nlm.nih.gov/pmc/articles/PMC9445423/

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   Does FN1 have diagnostic value?

   • To determine if FN1 has diagnostic value, we used a receiver operating characteristic (ROC) curve to assess the diagnostic value of FN1 mRNA expression. The results revealed that the area under the curve (AUC) of FN1 was 0.706 ( Figure 2A ).

   FN1 is a prognostic biomarker and correlated with immune infiltrates in

   www.ncbi.nlm.nih.gov/pmc/articles/PMC9445423/

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   What is the prognostic significance of fn1 in GC?

   • The KM plotter evaluates the prognostic significance of FN1 in GC, including overall survival (OS), first progression (FP), and postprogression survival (PPS). Hazard ratios (HRs) with 95% confidence intervals and log-rank p-values were also estimated. Statistical significance was defined as p < 0.05.

   FN1 is a prognostic biomarker and correlated with immune infiltrates in

   www.ncbi.nlm.nih.gov/pmc/articles/PMC9445423/

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   Are fn1-fgfr1 cells associated with ischemic necrosis in melanoma?

   • Identify FN1 (high)MITF (low) cell type in melanoma associated with ischemic necrosis, and propose these cells reside at the crossroad of the epithelial-to-mesenchymal transition and stem-like cell induction, plausibly triggered by the hypoxic environment. Report FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour.

   2335 - Gene ResultFN1 fibronectin 1 [ (human)] - National Center for

   www.ncbi.nlm.nih.gov/gene/2335

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7. medlineplus.gov › genetics › geneFN1 gene: MedlinePlus Genetics

   medlineplus.gov › genetics › gene

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   The FN1 gene provides instructions for making two types of the fibronectin-1 protein, which is involved in blood clotting, wound healing, and tissue repair. Learn about the normal function, health conditions, and related genes of the FN1 gene from MedlinePlus Genetics.

8. www.ncbi.nlm.nih.gov › geneFN1 fibronectin 1 [Homo sapiens (human)] - Gene - NCBI

   www.ncbi.nlm.nih.gov › gene

   Apr 30, 2024 · FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin.