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  1. The discovery in 1953 of the double helix, the twisted-ladder structure of deoxyribonucleic acid (DNA), by James Watson and Francis Crick marked a milestone in the history of science and gave rise to modern molecular biology, which is largely concerned with understanding how genes control the chemical processes within cells.

  2. www.nature.com › articles › d41586/019/02554-zThe structure of DNA

    Oct 9, 2019 · On 25 April 1953, James Watson and Francis Crick announced 1 in Nature that they “wish to suggest” a structure for DNA. In an article of just over a page, with one diagram (Fig. 1), they...

    • Georgina Ferry
    • 2019
    • Discovering The Structure of DNA
    • Rosalind Franklin
    • Maurice Wilkins
    • James Watson and Francis Crick
    • Separate Career Paths

    The molecule that is the basis for heredity, DNA, contains the patterns for constructing proteins in the body, including the various enzymes. A new understanding of heredity and hereditary disease was possible once it was determined that DNA consists of two chains twisted around each other, or double helixes, of alternating phosphate and sugar grou...

    Of the four DNA researchers, only Rosalind Franklin had any degrees in chemistry. She was born into a prominent London banking family, where all the children—girls and boys—were encouraged to develop their individual aptitudes. She attended Newnham College, one of the women’s colleges at Cambridge University. She completed her degree in 1941 in the...

    Already at work at King’s College was Maurice Wilkins, a New Zealand–born but Cambridge-educated physicist. As a new PhD he worked during World War II on the improvement of cathode-ray tube screens for use in radar and then was shipped out to the United States to work on the Manhattan Project. Like many other nuclear physicists, he became disillusi...

    Meanwhile, in 1951, 23-year-old James Watson, a Chicago-born American, arrived at the Cavendish Laboratory in Cambridge. Watson had two degrees in zoology: a bachelor’s degree from the University of Chicago and a doctorate from Indiana University, where he became interested in genetics. He had worked under Salvador E. Luria at Indiana on bacterioph...

    Then they moved off in different directions. Franklin went to Birkbeck College, London, to work in J. D. Bernal’s laboratory, a much more congenial setting for her than King’s College. Before her untimely death from cancer she made important contributions to the X-ray crystallographic analysis of the structure of the tobacco mosaic virus, a landmar...

  3. The DNA double helix structure proposed by Watson and Crick was based upon "Watson-Crick" bonds between the four bases most frequently found in DNA (A, C, T, G) and RNA (A, C, U, G). However, later research showed that triple-stranded, quadruple-stranded and other more complex DNA molecular structures required Hoogsteen base pairing .

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  4. In this article, we'll briefly explore how the double-helical structure of DNA was discovered through the work of James Watson, Francis Crick, Rosalind Franklin, and other researchers. Then, we'll take a look at the properties of the double helix itself.

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  6. Nov 24, 2009 · On February 28, 1953, Cambridge University scientists James D. Watson and Francis H.C. Crick announce that they have determined the double-helix structure of DNA, the molecule...

  7. The 3-dimensional double helix structure of DNA, correctly elucidated by James Watson and Francis Crick. Complementary bases are held together as a pair by hydrogen bonds.

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