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Mar 21, 2023 · WASHINGTON (WPIX) – The U.S. Drug Enforcement Administration has issued a public safety alert warning Americans about the widespread threat of fentanyl mixed with xylazine, an animal tranquilizer commonly referred to as “tranq.” "Xylazine is making the deadliest drug threat our country has ever faced, fentanyl, even deadlier," said DEA Administrator Ann Milgram.