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Giulia Farnese (1474 – 23 March 1524) was an Italian noblewoman, a mistress to Pope Alexander VI, and the sister of Pope Paul III. Known as, she was a member of the noble Farnese family, who were prominent leaders in the Italian regions of Parma and Piacenza. After marrying into the noble Orsini family in the Papal States, Farnese soon acquainted herself with, and initiated an affair with, the Spanish Cardinal Rodrigo de Borja. Wikipedia