Search results
Sep 18, 2020 · Its encoding gene, APOE, is tri-allelic at two loci in exon 4 that give rise to three haplotypes and six genotypes: e2 has cysteines at aa residues 112 and aa 158; e4 has arginines at these aa...
Feb 13, 2020 · The quantification of different genotypes was performed by monitoring four isoform-specific peptides: E2, E4, E2/E3, and E3/E4. In the comparisons of apoE isoforms in homozygous individuals (E2/E2, E3/E3, E4/E4), the concentrations of total apoE were divided by two.
- Karolina Minta, Gunnar Brinkmalm, Gunnar Brinkmalm, S. Janelidze, Simon Sjödin, Simon Sjödin, Erik P...
- 2020
Jul 16, 2010 · Go to: Abstract. The apolipoprotein E (APOE) genotype is a genetic risk factor for dementia, Alzheimer’s disease, and cardiovascular disease (CVD). It includes three alleles (e2, e3, e4) that are located on chromosome 19q3.2.
- Mary N. Haan, Elizabeth R. Mayeda
- 2010
1. Introduction. Apolipoprotein E (APOE) is a glycoprotein involved in cholesterol homeostasis and lipid metabolism, that is produced mainly by hepatocytes and astrocytes, and is found in plasma and cerebrospinal fluid.
- Amanda L. Lumsden, Anwar Mulugeta, Anwar Mulugeta, Ang Zhou, Elina Hyppönen
- 2020
Jul 14, 2022 · Highlights. - APOE e2 is the only replicated variant identified in the genome associated with longevity, though it is unclear if this is solely due to its effects on reducing AD risk or is partially due to other factors. -
- 10.3389/fnagi.2022.919712
- 2022
- Front Aging Neurosci. 2022; 14: 919712.
People also ask
Is APOE e4 a risk genotype?
What is the difference between APOE E3 vs E3/E4 genotyping?
What is APOE e4?
Are APOE E4 alleles associated with a higher risk for AD?
Nov 24, 2023 · The APOE E2/E4, E3/E3 genotype and ε2, ε3 allele frequency had significant difference between DM patients and controls (P<0.05). The DM patients with ɛ4 allele had lower level in high-density lipoprotein cholesterol (HDL-C) and higher level in apolipoprotein B (ApoB) than those with ɛ2 allele.
Aug 7, 2020 · The apolipoprotein E (APOE) e4 allele is the most common genetic variant associated with Alzheimer’s disease (AD), with the presence of an allele increasing the risk of developing AD 1, 2, 3, 4.
