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Feb 5, 2024 · The symptoms of GPA can vary greatly from person to person. For some, the disease is mild, while for others it may be severe or even life-threatening. GPA symptoms may come on slowly over a period of months or develop rapidly in a matter of days. Early symptoms can include: Runny nose/nasal congestion; Nosebleeds; Sinus pain; Ear pain; Hearing loss
Most people with GPA first have vague symptoms that may include: Tiredness or exhaustion. Joint pain. Upper respiratory symptoms that don’t respond to treatments for allergies or colds: Runny nose. Bloody discharge. Sinus pain. Congestion. Blockage of the eustachian tubes in the ears. Cough that produces blood. Shortness of breath.
Pathophysiology |. Symptoms and Signs |. Diagnosis |. Prognosis |. Treatment |. Key Points. Granulomatosis with polyangiitis is characterized by necrotizing granulomatous inflammation, small- and medium-sized vessel vasculitis, and focal necrotizing glomerulonephritis, often with crescent formation.
Symptoms of GPA vasculitis may range from mild to life-threatening and may develop quickly (over a few days) or slowly (over a few months). 1 Symptoms seen early in the disease can include: 3. upper respiratory symptoms resembling a cold. sinus pain, nasal congestion, and a runny nose. nosebleeds. hearing loss or ear pain. hoarseness.
It has been said that vasculitis is a “hurting disease”, because it is so commonly associated with pain of one type or another: pain from a nerve infarction, pain from insufficient blood to the gastrointestinal tract, pain from skin ulcers. In some cases, however, identifying the source and underlying cause of the pain is extremely challenging.
Jun 24, 2020 · Granulomatosis with polyangiitis (GPA) is a rare disorder characterized by inflammation of small- and medium-sized blood vessels (vasculitis) that results in damage to various organ systems of the body, most often the respiratory tract and kidneys.
The signs and symptoms of GPA are highly varied and reflect which organs are supplied by the affected blood vessels. Typical signs and symptoms include nosebleeds, stuffy nose and crustiness of nasal secretions, and inflammation of the uveal layer of the eye. [3] . Damage to the heart, lungs and kidneys can be fatal. The cause of GPA is unknown.
