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How did Mendel study the garden pea?
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What did Mendel discover?
By experimenting with pea plant breeding, Mendel developed three principles of inheritance that described the transmission of genetic traits, before anyone knew genes existed. Mendel's...
- Overview
- How can we study inheritance?
- The monk in the garden: Gregor Mendel
- Research on heredity
- Scientific legacy
- Mendel’s model system: The pea plant
- Mendel’s experimental setup
How Austrian monk Gregor Mendel laid the foundations of genetics. Mendel's life, experiments, and pea plants.
How can we study inheritance?
When spending time with your own family, friends, and neighbors, you may have noticed that many traits run in families. For instance, members of a family may share similar facial features, hair color (like the brother and sister below), or a predisposition to health problems such as diabetes. Characteristics that run in families often have a genetic basis, meaning that they depend on genetic information a person inherits from his or her parents.
What if you wanted to figure out how genetic information is transmitted between generations? For instance, you might be curious how traits can "skip" a generation, or why one child in a family may suffer from a genetic disease while another does not. How could you go about asking these kinds of questions scientifically?
An obvious first idea would be to study human inheritance patterns directly, but that turns out to be a tricky proposition (see the pop-up below for details). In this article, we'll see how a nineteenth-century monk named Gregor Mendel instead uncovered the key principles of inheritance using a simple, familiar system: the pea plant.
[Why didn't Mendel study humans?]
When spending time with your own family, friends, and neighbors, you may have noticed that many traits run in families. For instance, members of a family may share similar facial features, hair color (like the brother and sister below), or a predisposition to health problems such as diabetes. Characteristics that run in families often have a genetic basis, meaning that they depend on genetic information a person inherits from his or her parents.
What if you wanted to figure out how genetic information is transmitted between generations? For instance, you might be curious how traits can "skip" a generation, or why one child in a family may suffer from a genetic disease while another does not. How could you go about asking these kinds of questions scientifically?
An obvious first idea would be to study human inheritance patterns directly, but that turns out to be a tricky proposition (see the pop-up below for details). In this article, we'll see how a nineteenth-century monk named Gregor Mendel instead uncovered the key principles of inheritance using a simple, familiar system: the pea plant.
[Why didn't Mendel study humans?]
Johann Gregor Mendel (1822–1884), often called the “father of genetics,” was a teacher, lifelong learner, scientist, and man of faith. It would be fair to say that Mendel had a lot of grit: he persevered through difficult circumstances to make some of the most important discoveries in biology.
As a young man, Mendel had difficulty paying for his education due to his family's limited means, and he also suffered bouts of physical illness and depression; still, he persevered to graduate from high school and, later, university1 . After finishing university, he joined the Augustinian Abbey of St. Thomas in Brno, in what is now the Czech Republic. At the time, the monastery was the cultural and intellectual hub of the region, and Mendel was immediately exposed to new teachings and ideas1 .
In 1856, Mendel began a decade-long research project to investigate patterns of inheritance. Although he began his research using mice, he later switched to honeybees and plants, ultimately settling on garden peas as his primary model system2 . A model system is an organism that makes it easy for a researcher to investigate a particular scientific question, such as how traits are inherited. By studying a model system, researchers can learn general principles that apply to other, harder-to-study organisms or biological systems, such as humans.
Mendel studied the inheritance of seven different features in peas, including height, flower color, seed color, and seed shape. To do so, he first established pea lines with two different forms of a feature, such as tall vs. short height. He grew these lines for generations until they were pure-breeding (always produced offspring identical to the parent), then bred them to each other and observed how the traits were inherited.
In addition to recording how the plants in each generation looked, Mendel counted the exact number of plants that showed each trait. Strikingly, he found very similar patterns of inheritance for all seven features he studied:
•One form of a feature, such as tall, always concealed the other form, such as short, in the first generation after the cross. Mendel called the visible form the dominant trait and the hidden form the recessive trait.
•In the second generation, after plants were allowed to self-fertilize (pollinate themselves), the hidden form of the trait reappeared in a minority of the plants. Specifically, there were always about 3 plants that showed the dominant trait (e.g., tall) for every 1 plant that showed the recessive trait (e.g., short), making a 3:1 ratio.
•Mendel also found that the features were inherited independently: one feature, such as plant height, did not influence inheritance of other features, such as flower color or seed shape.
Mendel's work went largely unnoticed by the scientific community during his lifetime. How could this have been the case?
In part, Mendel's contemporaries failed to recognize the importance of his work because his findings went against prevailing (popular) ideas about inheritance. In addition, although we now see Mendel's mathematical approach to biology as innovative and pioneering, it was new, unfamiliar, and perhaps confusing or unintuitive to other biologists of the time5 .
In the mid-1800s, when Mendel was doing his experiments, most biologists subscribed to the idea of blending inheritance. Blending inheritance wasn't a formal, scientific hypothesis, but rather, a general model in which inheritance involved the permanent blending of parents' characteristics in their offspring (producing offspring with an intermediate form of a characteristic)6 . The blending model fit well with some observations of human inheritance: for instance, children often look a bit like both of their parents.
But the blending model could not explain why Mendel crossed a tall and a short pea plant and got only tall plants, or why self-fertilization of one of those tall plants would produce a 3:1 ratio of tall to short plants in the next generation. Instead, if the blending model were correct, a tall plant crossed with a short plant should produce a medium plant, which would go on to produce more medium plants (see below).
As it turns out, both pea plant height and human height (along with many other characteristics in a wide range of organisms) are controlled by pairs of heritable factors that come in distinctive versions, just as Mendel proposed. In humans, however, there are many different factors (genes) that contribute fractionally to height and vary among individuals. This makes it difficult to see the contribution of any one factor and produces inheritance patterns that can resemble blending. In Mendel's experiments, in contrast, there was just one factor that differed between the tall and short pea plants, allowing Mendel to clearly see the underlying pattern of inheritance.
In 1868, Mendel became abbot of his monastery and largely set aside his scientific pursuits in favor of his pastoral duties. He was not recognized for his extraordinary scientific contributions during his lifetime. In fact, it was not until around 1900 that his work was rediscovered, reproduced, and revitalized. Its rediscoverers were biologists on the brink of discovering the chromosomal basis of heredity – that is, about to realize that Mendel's “heritable factors” were carried on chromosomes.
Mendel carried out his key experiments using the garden pea, Pisum sativum, as a model system. Pea plants make a convenient system for studies of inheritance, and they are still studied by some geneticists today.
Useful features of peas include their rapid life cycle and the production of lots and lots of seeds. Pea plants also typically self-fertilize, meaning that the same plant makes both the sperm and the egg that come together in fertilization. Mendel took advantage of this property to produce true-breeding pea lines: he self-fertilized and selected peas for many generations until he got lines that consistently made offspring identical to the parent (e.g., always short).
Pea plants are also easy to cross, or mate in a controlled way. This is done by transferring pollen from the anthers (male parts) of a pea plant of one variety to the carpel (female part) of a mature pea plant of a different variety. To prevent the receiving plant from self-fertilizing, Mendel painstakingly removed all of the immature anthers from the plant’s flowers before the cross.
Once Mendel had established true-breeding pea lines with different traits for one or more features of interest (such as tall vs. short height), he began to investigate how the traits were inherited by carrying out a series of crosses.
First, he crossed one true-breeding parent to another. The plants used in this initial cross are called the P generation, or parental generation.
Mendel collected the seeds from the P generation cross and grew them up. These offspring were called the F1 generation, short for first filial generation. (Filius means “son” in Latin, so this name is slightly less weird than it seems!)
Once Mendel examined the F1 plants and recorded their traits, he let them self-fertilize naturally, producing lots of seeds. He then collected and grew the seeds from the F1 plants to produce an F2 generation, or second filial generation. Again, he carefully examined the plants and recorded their traits.
Mendel's experiments extended beyond the F2 generation to F3 , F4 , and later generations, but his model of inheritance was based mostly on the first three generations (P , F1 , and F2 ).
Mendel didn’t just record what his plants looked like in each generation (e.g., tall vs. short). Instead, he counted exactly how many plants with each trait were present. This may sound tedious, but by recording numbers and thinking mathematically, Mendel made discoveries that eluded famous scientists of his time (such as Charles Darwin, who carried out similar experiments but didn’t grasp the significance of his results)5 .
Mendel’s model system: The pea plant. Mendel carried out his key experiments using the garden pea, Pisum sativum, as a model system. Pea plants make a convenient system for studies of inheritance, and they are still studied by some geneticists today. Useful features of peas include their rapid life cycle and the production of lots and lots of ...
May 8, 2019 · Learn how Gregor Mendel, a 19th-century pioneer of genetics, studied the different traits of pea plants and discovered the laws of heredity. Find out how he performed monohybrid and dihybrid crosses, and what he observed from the F1, F2 and P generations.
Apr 22, 2013 · Learn how Gregor Mendel used peas to study heredity and discover the laws of inheritance. Explore his experiments, results, and discoveries with this online education kit from Genome.gov.
In 1865, Mendel presented the results of his experiments with nearly 30,000 pea plants to the local natural history society. He demonstrated that traits are transmitted faithfully from parents to offspring in specific patterns.
May 13, 2020 · The plants are common garden peas, and they were studied in the mid-1800s by an Austrian monk named Gregor Mendel. With his careful experiments, Mendel uncovered the secrets of heredity, or how parents pass characteristics to their offspring.
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