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  1. All roles for the series are cast without the characters' races being pre-specified, in keeping with Rhimes' vision of diversity. The series' protagonist, Meredith Grey, is portrayed by Ellen Pompeo. Pompeo starred in the leading role in Moonlight Mile, which led to her being cast as Meredith.

  2. Grey's Anatomy: Created by Shonda Rhimes. With Ellen Pompeo, Chandra Wilson, James Pickens Jr., Justin Chambers. A drama centered on the personal and professional lives of five surgical interns and their supervisors.

  3. Follow Grey's Anatomy: Meet the cast and hosts of Grey's Anatomy, read their bios, top moments, and view their photos, videos and more at ABC.com.

  4. Learn more about the full cast of Grey's Anatomy with news, photos, videos and more at TV Guide.

  5. Grey's Anatomy is an American television medical drama series created by Shonda Rhimes and broadcast by ABC. The show features an ensemble cast of lead characters, along with multiple supporting cast members. During its first season, the show featured nine lead characters.

  6. The original cast consisted of nine star-billed actors: Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, T. R. Knight, Chandra Wilson, James Pickens Jr., Isaiah Washington, and Patrick Dempsey.

  7. ‘Grey’s Anatomy’ Season 20 Cast and Character Guide Get to know the performers at the center of the longest-running medical drama in television history Niko Terho, Ellen Pompeo and Chandra...

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