Search results
Mar 31, 2017 · This Review explores the history of Rocky Mountain spotted fever in Mexico, current epidemiology, and the multiple clinical, economic, and social challenges that must be considered in the control and prevention of this life-threatening illness.
- Gerardo Álvarez-Hernández, Jesús Felipe González Roldán, Néstor Saúl Hernández Milan, R Ryan Lash, C...
- 2017
Jan 11, 2024 · Includes information and data on the risk, number of cases, and geographic distribution of reported cases of spotted fever rickettsiosis including Rocky Mountain spotted fever.
People also ask
What are the epidemiological features of Rocky Mountain spotted fever?
Who discovered Rocky Mountain spotted fever?
Is Rocky Mountain spotted fever fatal in Sonora Mexico?
- Abstract
- Methods
- Results
- Discussion
- Limitations
- Conclusions
- Notes
Rocky Mountain spotted fever (RMSF) is a potentially deadly tickborne disease caused by the bacterium Rickettsia rickettsii. RMSF is a rapidly progressing illness; bacteria invade endothelial cells throughout the body resulting in disrupted organ perfusion, sepsis, and sometimes death . Prior to antibiotic therapy, case fatality rates from RMSF wer...
We used a convenience sample of individuals hospitalized with RMSF during 2002–2017 from 2 highly impacted communities in Arizona. Cases were identified using data reported to the Arizona Department of Health Services. For the purposes of this study, long-term sequelae (LTS) are defined as symptoms reported by patients or signs identified on exam f...
Medical records from 80 hospitalized cases of RMSF with illness during 2002–2017 were evaluated based on those meeting inclusion criteria. Half of the patients (n = 40 [50%]) were female, and median age was 15 years (IQR, 4–41 years). Seventeen cases (21%) resulted in a fatal outcome.
Acute Disease Findings
Our findings provide further evidence of the severe and fatal nature of RMSF. The case fatality rate was 21% in our cohort, which is higher than the estimated 5%–10% for the United States . However, since we included only hospitalized cases, it is likely we captured those with more severe disease. High proportions of fatal outcome are consistent with reports from Mexicali and Sonora [19, 20]. The clinical descriptions of RMSF cases were similar to what has been reported in previous summari...
Recovery and Long-term Sequelae
Nearly half of the surviving individuals agreed to participate in the patient survey, providing key insight into disease recovery. Most patients reported full recovery with a mean time of 12 days to normal function. While time to defervescence and discharge have been previously reported, to our knowledge this is the first report on time to disease recovery. A substantial proportion (23%) of individuals had evidence of LTS from RMSF based on neurologic exam and reported neurologic symptoms. Th...
Predictors of Long-term Sequelae
Individual clinical findings during hospitalization, presence of 1 or more elements of severe disease, and presence of neurologic sequelae at discharge were not significantly predictive of the development of LTS. Our ability to identify statistically significant predictors of LTS may, however, be limited by the small sample size of individuals with LTS. Delay in doxycycline administration is the strongest predictor of LTS by logistic regression. Survival analysis demonstrates precipitous chan...
This study relies on convenience sampling of RMSF patients in specific Arizona tribal communities. While the findings are not yet proven to have external validity to other areas or to nonhospitalized cases, this cohort is the largest group of patients with RMSF known in the United States and provides substantial evidence of severe disability follow...
RMSF is a deadly and debilitating illness. While most individuals with severe RMSF experience complete recovery in 1–2 weeks following illness, roughly 1 in 4 patients may experience persistent or even permanent neurologic sequelae. We documented neurologic sequelae up to 11 years following acute disease. While most of the patients with LTS had 1 o...
Acknowledgments.The authors acknowledge the contributions of the following individuals for their support during the medical record abstraction: Yari Torres-Mendoza, Stefanie Campbell, Carla Bezold, Cara Cherry, Edwin Rodriguez, Nicole Fowle, and Mary-Helen Wanat. The authors also thank Drs Sarah Coles, Mandy Boltz, and Christine Gill for their help...
This Review explores the history of Rocky Mountain spotted fever in Mexico, current epidemiology, and the multiple clinical, economic, and social challenges that must be considered in the control and prevention of this life-threatening illness.
Apr 29, 2017 · This Review explores the history of Rocky Mountain spotted fever in Mexico, current epidemiology, and the multiple clinical, economic, and social challenges that must be considered in the...
Aug 11, 2005 · Epidemiology and Clinical Features of Rocky Mountain Spotted Fever from Enhanced Surveillance, Sonora, Mexico: 2015–2018, The American Journal of Tropical Medicine and Hygiene, 104, 1, (190-197 ...
Nov 2, 2020 · INTRODUCTION. Rocky Mountain spotted fever (RMSF) is a severe and potentially fatal tick-borne disease caused by infection with Rickettsia rickettsii, which is transmitted by several species of ticks of the genus Dermacentor (Dermacentor variabilis and Dermacentor andersoni), Rhipicephalus (Rhipicephalus sanguineus), and Amblyomma (Amblyomma cajennense, Amblyomma aureolatum, Amblyomma imitator ...
