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"Houston, we have a problem" is popularly quoted as a phrase spoken during Apollo 13, a NASA mission in the Apollo space program and the third meant to land on the Moon. After an explosion occurred on board the spacecraft en route to the Moon at 55:54:53, Jack Swigert, the command module pilot, reported to Mission Control Center in Houston, Texas: "Okay, Houston ... we've had a problem here." Afte... Wikipedia