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Abstract. Entamoeba histolytica represents one of the leading causes of parasitic death worldwide. Although identified as the causative agent of amebiasis since 1875, the molecular mechanisms by which the parasite causes disease are still not fully understood. Studying Entamoeba reveals insights into a eukaryotic cell that differs in many ways ...
- Laura Morf, Upinder Singh
- 10.1016/j.mib.2012.04.011
- 2012
- 2012/08
Entamoeba cells are small, with a single nucleus and typically a single lobose pseudopod taking the form of a clear anterior bulge. They have a simple life cycle. The trophozoite (feeding-dividing form) is approximately 10-20 μm in diameter and feeds primarily on bacteria. It divides by simple binary fission to form two smaller daughter cells.
- Entamoeba, Casagrandi & Barbagallo, 1897
- Entamoebidae
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Oct 31, 2022 · Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This parasite has caused widespread infection in India, Africa, Mexico, and Central and South America, and results in 100,000 deaths yearly. An immune response is ...
- 10.3390/membranes12111079
- 2022/11
- Membranes (Basel). 2022 Nov; 12(11): 1079.
Morphology and Biology Entamoeba histolytica occurs in the following forms, the tro-phozoites,precyst,cyst,metacyst,andmetacystictrophozoite. The trophozoite is about 10–60 μm in size with a clear finely granular cytoplasm and a spherical nucleus that shows aggre-gation of chromatin beads at the nuclear membrane and a centrally located ...
- Nadia A. El-Dib
- 2017
- Carolina Mendoza Cavazos, Laura J. Knoll
- 2020
- Rodent models do not mimic the entire life cycle of E. histolytica. Entamoeba histolytica is an extracellular enteric eukaryotic parasite. Globally, an average of 50 million cases and 55,000 to 100,000 deaths are due to E. histolytica infection each year, primarily impacting the developing world [1,2].
- Trophozoites can initiate infection in rodent models. A robust way to culture trophozoites has been developed in the laboratory setting [13] and has been the primary resource to perform in vivo infection.
- E. histolytica invasive disease can be modeled in rodents. E. histolytica disease outcomes range widely in humans: death, sepsis, liver abscesses, ulcers, dysentery, abdominal pain and mucoid diarrhea with occasional blood, and asymptomatic shedding.
- Disease modeling in rodents has shown microbiome–host–parasite interactions. Recent literature suggests that the host microbiome is a modifier of disease outcome and parasite development.
Ingested RBC; distinctive nucleus Cyst Stage: Chromatoidal body 'Cigar' shaped bodies (made up of crystalline ribosomes) Number of nuclei: 1 in early stages, 4 when mature Pathognomonic/diagnostic feature 'Ring and dot' nucleus and chromatoid bodies
Entamoeba hartmanni, also in the quadrinucleate cyst clade, is much smaller than E. histolytica with cysts reaching only 10 μm in diameter and trophozoites of 3–12 μm in diameter. The larger cysts of E. coli may possess as many as eight nuclei and can be identified by splinter-like chromatid bodies in their cytoplasm.
