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  2. Feb 10, 2023 · Humans usually get Lyme disease from the bite of a tick carrying the bacteria. Ticks that can carry borrelia bacteria live throughout most of the United States. But Lyme disease is most common in the upper Midwest and the northeastern and mid-Atlantic states.

  3. Lyme disease is caused by bacteria that is spread to humans by tick bites. The ticks that carry the spirochete are: Black-legged deer tick (northeastern, mid-Atlantic, and North-Central U.S.) Western black-legged tick (Pacific coastal U.S.) Ticks prefer to live in wooded areas, low-growing grasslands, and yards.

  4. A typical tick bite site reaction is dime-sized or smaller and does not enlarge each day like the erythema migrans rash of Lyme disease. Bacteria from the Lyme disease rash can disseminate through the bloodstream and create new erythema migrans skin lesions at other sites distant from the initial bite.

  5. Nymphal ticks cause most cases of Lyme disease. Because nymphs are as small as poppy seeds and their bite is painless, people often don’t realize they have been bitten. Adult ticks can also infect humans, but are easier to spot and remove. Not all ticks are infected.

  6. The deposition of spirochetes into human dermal tissue generates a local inflammatory response that manifests as erythema migrans (EM), the hallmark skin lesion. If treated appropriately and early, the prognosis is excellent.

    • Justin D Radolf, Klemen Strle, Jacob E Lemieux, Franc Strle
    • 10.21775/cimb.042.333
    • 2022
    • 2021
  7. Lyme disease is most frequently reported from the upper midwestern, northeastern, and mid-Atlantic states where it is spread by Ixodes scapularis ticks. Some cases are also reported from northern California, Oregon, and Washington, where it is spread by Ixodes pacificus ticks.

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