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Oct 9, 2012 · The mechanism of selenocysteine synthesis. Selenocysteine, also known as the 21st amino acid, is unique among the proteinogenic amino acids. It is the only amino acid containing an essential dietary micronutrient (selenium) as a constitutive component, the only amino acid encoded by a UGA codon and the only one synthesized on its tRNA in all domains of life.
- Figure 4
The essentiality of the selenocysteine cycle has also been...
- Table 1
Table 1. Human selenoproteins, physiological role, and...
- Open in a Separate Window
Point mutations in SepSecS give rise to progressive...
- The Selenocysteine-specific Elongation Factor Contains a Novel and Multi-functional Domain
The selenocysteine (Sec)-specific eukaryotic elongation...
- Secis
Interestingly, the serylated precursor from which Sec is...
- PMC Free Article
Baron C, Böck A (1991) The length of the aminoacyl-acceptor...
- Structure of a tRNA-dependent Kinase Essential for Selenocysteine Decoding
Overall Structure. The crystal structure of MjPSTK was...
- Figure 4
Selenocysteine (symbol Sec or U, [4] in older publications also as Se-Cys) [5] is the 21st proteinogenic amino acid. Selenoproteins contain selenocysteine residues. Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur . Selenocysteine is present in several enzymes (for example glutathione peroxidases ...
- C₃H₇NO₂Se
- .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}10236-58-5
- 168.065 g·mol−1
- CHEBI:16633
Nov 15, 2022 · Abstract. Selenocysteine (Sec), the 21st genetically encoded amino acid, is structurally similar to cysteine (Cys) but with a sulfur to selenium replacement. This small change confers Sec with related chemical properties to Cys but often with enhanced reactivity. In organisms, Sec is present in selenoproteins taking on various roles such as ...
Aug 1, 2013 · Abstract. Selenium is an essential trace element that is incorporated into 25 human proteins as the amino acid selenocysteine (Sec). The incorporation of this amino acid turns out to be a fascinating problem in molecular biology because Sec is encoded by a stop codon, UGA. Layered on top of the canonical translation elongation machinery is a ...
- Jonathan N. Gonzalez-Flores, Sumangala P. Shetty, Aditi Dubey, Paul R. Copeland
- 10.1515/bmc-2013-0007
- 2013
- 2013/08/08
Oct 30, 2005 · Abstract. Selenocysteine (Sec), the 21st amino acid, exists naturally in all kingdoms of life as the defining entity of selenoproteins. Sec is a cysteine (Cys) residue analogue with a selenium-containing selenol group in place of the sulfur-containing thiol group in Cys. The selenium atom gives Sec quite different properties from Cys.
- Linda Johansson, Guro Gafvelin, Elias S.J. Arnér
- 2005
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What is selenocysteine (Sec)?
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What is selenocysteine & why is it important?
As shown in Fig. 10.1 , selenide is the key compound for selenoprotein biosyn-thesis . A selenocysteine residue is encoded by the UGA codon in selenoprotein mRNA , which is decoded by selenocysteyl-tRNA [Ser]Sec [ 3 , 4 ]. The selenocysteine moiety on selenocysteyl-tRNA [Ser]Sec is biosynthesized using selenophosphate ,
The intermediate Ser-tRNA [Ser]Sec is delivered to selenocysteine synthase–SelA in Bacteria–or phosphoseryl-tRNA kinase–PSTK in Archaea/Eukarya–for Ser/Sec conversion. In bacteria, the homodecameric SelA, a pyridoxal-5′-phosphate (PLP) dependence enzyme, is responsible for this conversion forming a ternary 1.3 MDa complex machinery ...
