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Oct 9, 2012 · In all selenocysteine-containing organisms, the synthetic cycle of selenocysteine begins with an essential “error:” seryl-tRNA synthetase (SerRS) “erroneously” charges selenocysteine tRNA (tRNA Sec) with serine thus yielding seryl-tRNA Sec (Figure 1).
- Table 1
Table 1. Human selenoproteins, physiological role, and...
- Open in a Separate Window
Point mutations in SepSecS give rise to progressive...
- The Selenocysteine-specific Elongation Factor Contains a Novel and Multi-functional Domain
The selenocysteine (Sec)-specific eukaryotic elongation...
- Secis
Background: Selenocysteine incorporation requires unique...
- Structure of a tRNA-dependent Kinase Essential for Selenocysteine Decoding
Overall Structure. The crystal structure of MjPSTK was...
- Table 1
Nov 15, 2022 · In bacteria, Ser-tRNA Sec is converted to Sec-tRNA Sec in a single step by selenocysteine synthase (SelA). In eukaryotes this process occurs in two separate steps: i) phosphorylation of Ser by O -phosphoseryl-tRNA kinase (PSTK) then ii) conversion of phosphoserine (Sep) to Sec by Sep-tRNA:Sec-tRNA synthase (SepSecS).
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How selenocysteine is encoded in selenoprotein mRNA?
What is selenocysteine tRNA synthetase (SerRS)?
How is selenocysteine encoded?
What is selenocysteine (Sec)?
In eukaryotes and archaea, two enzymes are required to convert tRNA-bound seryl residue into tRNA selenocysteinyl residue: PSTK (O-phosphoseryl-tRNA[Ser]Sec kinase) and selenocysteine synthase.
- C₃H₇NO₂Se
- .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}10236-58-5
- 168.065 g·mol−1
- CHEBI:16633
A selenocysteine residue is encoded by the UGA codon in selenoprotein mRNA , which is decoded by selenocysteyl-tRNA [Ser]Sec [ 3 , 4 ]. The selenocysteine moiety on selenocysteyl-tRNA [Ser]Sec is biosynthesized using selenophosphate , which is produced from selenide and ATP by selenophosphate synthetase [ 5 , 6 ].
An alternative to keep low toxicity levels is recycling selenium compound into the biological and useful source as selenophosphate. This conversion involves a non-Sec pathway-specific enzyme–selenocysteine lyase (CsdB)–that drives the Sec recycling to selenide, which is highly toxic for the cells.
- Vitor Hugo Balasco Serrão, Jessica Fernandes Scortecci
- 2020
Aug 1, 2013 · Selenocysteine incorporation can be thought of as a specialized elongation cycle, where a dedicated, selenocysteine-specific elongation factor that binds only Sec-tRNA Sec, replaces eEF1A. This G-protein is present in both eukaryotes and prokaryotes as eEFSec and SelB respectively, and is required for the co-translational incorporation of ...
Jan 22, 2020 · On another hand, in Archaea and Eukarya the Sec biosynthesis is different and divided into two distinguished steps. The initial Ser residue present in the Ser-tRNA [Ser]Sec is phosphorylated by PSTK, resulting in an intermediate o-phosposeryl-(Sep)-tRNA [Sep]Sec.
