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Oct 9, 2012 · The mechanism of selenocysteine synthesis. Selenocysteine, also known as the 21st amino acid, is unique among the proteinogenic amino acids. It is the only amino acid containing an essential dietary micronutrient (selenium) as a constitutive component, the only amino acid encoded by a UGA codon and the only one synthesized on its tRNA in all domains of life.
- Table 1
Selenocysteine, the 21st amino acid, has been found in 25...
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Point mutations in SepSecS give rise to progressive...
- The Selenocysteine-specific Elongation Factor Contains a Novel and Multi-functional Domain
The selenocysteine (Sec)-specific eukaryotic elongation...
- Secis
Background: Selenocysteine incorporation requires unique...
- PMC Free Article
Baron C, Böck A (1991) The length of the aminoacyl-acceptor...
- Structure of a tRNA-dependent Kinase Essential for Selenocysteine Decoding
Overall Structure. The crystal structure of MjPSTK was...
- Table 1
Mar 10, 2011 · Mouse models that target removal or over-expression of the selenocysteine tRNA[Ser]Sec gene to elucidate the role of selenoproteins in health and development. : Hatfield DL, Berry MJ, Gladyshev VN, Selenium: its molecular biology and role in human health. New York: Springer; In press 2011 [Google Scholar]
- Anton A. Turanov, Xue-Ming Xu, Bradley A. Carlson, Min-Hyuk Yoo, Vadim N. Gladyshev, Dolph L. Hatfie...
- 10.3945/an.110.000265
- 2011
- Adv Nutr. 2011 Mar; 2(2): 122-128.
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Aug 1, 2013 · The existence of a selenium-laden tRNA was first observed in experiments performed in rat liver where radiolabeled [75 Se]-selenite was associated with a tRNA-bound selenocysteine residue . In a follow-up article, Hawkes and Tappel showed that GPX incorporated [ 75 Se]-Sec when [ 75 Se]-Sec-tRNA was added in cell-free extracts from rat liver ...
- Jonathan N. Gonzalez-Flores, Sumangala P. Shetty, Aditi Dubey, Paul R. Copeland
- 10.1515/bmc-2013-0007
- 2013
- 2013/08/08
Selenocysteine (symbol Sec or U, [4] in older publications also as Se-Cys) [5] is the 21st proteinogenic amino acid. Selenoproteins contain selenocysteine residues. Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur . Selenocysteine is present in several enzymes (for example glutathione peroxidases ...
- C₃H₇NO₂Se
- .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}10236-58-5
- 168.065 g·mol−1
- CHEBI:16633
A selenocysteine residue is encoded by the UGA codon in selenoprotein mRNA , which is decoded by selenocysteyl-tRNA [Ser]Sec [ 3 , 4 ]. The selenocysteine moiety on selenocysteyl-tRNA [Ser]Sec is biosynthesized using selenophosphate , which is produced from selenide and ATP by selenophosphate synthetase [ 5 , 6 ].
Oct 11, 2011 · The key steps in the replacement of Sec with Cys are: (1) sulfide can substitute for selenide in the SPS2 catalyzed reaction yielding thiophosphate; and (2) thiophosphate can react with the O-phosphoseryl-tRNA [Ser]Sec intermediate which is most likely dehydroalanine that was generated by the interaction of SecS to yield Sec tRNA [Ser]Sec (Fig ...
Another way to incorporate a selenocysteine residue into a protein is to use selenocysteine itself to cleave the thioester produced by intein fusion (strategy 4 in Table I). A 30-ml solution of 0.10 M selenocysteine is prepared as follows.
