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Oct 9, 2012 · Emerging evidence suggests that enzymes responsible for selenocysteine formation and decoding the selenocysteine UGA codon, which by extension are critical for synthesis of the entire selenoproteome, are essential for the development and health of the human organism.
- Table 1
Selenocysteine, the 21st amino acid, has been found in 25...
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Point mutations in SepSecS give rise to progressive...
- The Selenocysteine-specific Elongation Factor Contains a Novel and Multi-functional Domain
The selenocysteine (Sec)-specific eukaryotic elongation...
- Secis
Background: Selenocysteine incorporation requires unique...
- Structure of a tRNA-dependent Kinase Essential for Selenocysteine Decoding
Overall Structure. The crystal structure of MjPSTK was...
- Table 1
Jul 6, 2019 · In this review, the role of selenium and its possible routes in translational decoding of selenocysteine, synthesis of selenoproteins, systemic action of selenoproteins and their indirect assimilation in the process of wound healing are explained in detail.
- Sneha Hariharan, Selvakumar Dharmaraj
- 10.1007/s10787-020-00690-x
- 2020
- Inflammopharmacology. 2020; 28(3): 667-695.
Nov 15, 2022 · The requirement for ingesting Se-containing food is to provide the precursor for formation of selenocysteine (Sec), the 21st genetically encoded amino acid. Sec is a cysteine (Cys) analog where the thiol group has been replaced by a selenol moiety.
Jan 31, 2022 · In eukaryotes and archaea, tRNA-bound serine residue is converted into Sec by three enzymes: O-phosphoseryl-tRNA [Ser] Sec kinase (PSTK), selenophosphate synthetase 2 (SEPHS2), and Sec synthase (SEPSECS).
- Waldemar B. Minich
- 2022
- 10.1134/S0006297922140139
Biology. Applications. See also. References. Further reading. External links. Selenocysteine (symbol Sec or U, [4] in older publications also as Se-Cys) [5] is the 21st proteinogenic amino acid. Selenoproteins contain selenocysteine residues. Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur .
- C₃H₇NO₂Se
- .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}10236-58-5
- 168.065 g·mol−1
- CHEBI:16633
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Free selenomethionine is easily available through the digestion of dietary proteins and is further metabolized to selenocysteine via a selenium version of the transsulfuration pathway [ 11 ]. In addi-tion, selenomethionine is degraded by cystathionine -lyase to produce methane- γ.
Dietary selenium is obtained in the form of selenomethionine (SeMet), selenocysteine (Sec), selenite, and selenate. Sig- nificant health benefits have been attributed to selenium metabolic...
