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  1. Sep 30, 2021 · 3. Transmission and Replication Cycle of Dengue Virus inside Mammalian Cell. The Dengue virus is transmitted by female mosquitoes, mainly of the species Aedes aegypti, and to a lesser extent by a few other species such as Aedes albopictus, Aedes polynesiensis, Aedes scutellaris, etc. The virus is transmitted to humans from an infected mosquito ...

  2. Dengue virus replication. The dengue virus attaches to the surface of a host cell and enters the cell by a process called endocytosis. Once deep inside the cell, the virus fuses with the endosomal ...

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  4. The dengue viral replication process begins when the virus attaches to a human skin cell (Figure 4). After this attachment, the skin cell's membrane folds around the virus and forms a pouch that ...

  5. Apr 22, 2024 · Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each year, millions of people contract the virus through bites from infected female mosquitoes of the Aedes species. In the majority of individuals, the infection is asymptomatic, and the immune ...

  6. However, the presence of an antibody-dependent enhancement of dengue infection towards severe disease seems fundamental from four decades of research in this area. A significant amount of research has gone into understanding the cellular basis of DV replication and the intracellular events that govern virus replication and morphogenesis.

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