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- Agents with ‘sufficient evidence of carcinogenicity’ in humans are assigned by default to the highest category, ‘carcinogenic to humans’ (IARC Group 1) whereas the categories of ‘probably’ (Group 2A) or ‘possibly’ (Group 2B) carcinogenic to humans, or ‘not classifiable as to its carcinogenicity to humans’ (Group 3) are assigned according to the combined strength of the human, animal and mechanistic evidence.
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Dec 1, 2023 · Read the IARC Monographs Q&A for answers to commonly asked questions on the evaluation process. Note: In September 2022, four additional individual Group 1 agents were created by splitting up some existing agent groupings because not all agents in the groups had the same cancer sites with sufficient and limited evidence for cancer in humans.
Key Cancer Data and Key Figures on IARC: 2020–2021. The visuals presented here complement the Biennial Report of the International Agency for Research on Cancer (IARC) for the period 2020–2021. They show key cancer data for 2020 and key figures on IARC during the 2020–2021 biennium.
- Abstract
- Motivation and Process For Preamble Revision
- Key Changes in The Revised Preamble
- Funding
- Notes
For nearly 50 years, the Monographs program of the International Agency for Research on Cancer (IARC) has been a premier global resource for identifying agents that can cause cancer. The identification of carcinogenic hazards is a necessary initial step in cancer prevention. National and international authorities and organizations use information o...
Since 2006, substantial growth has occurred in the scientific understanding of factors contributing to carcinogenicity as well as in the development of methods for information gathering, evidence assessment, and integration. In 2018, the IARC convened an “Advisory Group to Recommend an Update to the Preamble,” with broad expertise across multiple d...
General Procedures
The advisory group encouraged the IARC to clarify the purpose and scope of the Monographs evaluations. In this regard, the name of the Monographs series has been changed to the IARC Monographs on the Identification of Carcinogenic Hazards to Humans. This change, although semantic in nature, reflects the important distinction between hazard and risk: Hazard refers to the strength of the evidence that an agent is a carcinogen, whereas risk refers to the probability that a given exposure to a ca...
Scientific Review and Evaluation
The revised Preamble defines how the principles of systematic review (eg, formal consideration of quality of the studies, such as design and methodology, and the reporting of results that are tailored to each stream of evidence and the types of studies available) apply to IARC assessments and how evaluations are reached to clearly articulate the rationales for expert judgments. At the same time, it is designed to be flexible enough to enable incorporation of further scientific advances as the...
This work was supported by the German Ministry of Health and the International Agency for Research on Cancer.
The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the International Agency for Research on Cancer, the US Centers for Disease Control and Prevention, the US Food and Drug Administration, the US Environmental Protection Agency, or the US National Institute of Environmental...
- Jonathan M Samet, Weihsueh A Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M Lunn, Fre...
- 2020
Mar 30, 2012 · We are pleased to announce the publication of a list of carcinogenic agents - by cancer site - with sufficient or limited evidence in humans. The list will be updated regularly as new classifications are announced. See List of Classifications by Cancer Site IARC Monographs website.
Jun 16, 2023 · 16 June 2023. IARC Monographs hazard classification. This infographic presents the categories used by the IARC Monographs on the Identification of Carcinogenic Hazards to Humans to classify a substance according to the level of certainty that the substance can cause cancer.
Nov 14, 2012 · Overview. Volume 100 of the IARC Monographs, A Review of Human Carcinogens, covers all agents previously classified by IARC as "carcinogenic to humans (Group 1)" and was developed by six separate Working Groups: Pharmaceuticals; Biological agents; Arsenic, Metals, Fibres, and Dusts; Radiation; Personal Habits and Indoor Combustions; Chemical ...
