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  1. www.ncbi.nlm.nih.gov › pmc › articlesTetracycline Antibiotics: Mode of Action, Applications, Molecular...

    It is well established that tetracyclines inhibit bacterial protein synthesis by preventing the association of aminoacyl-tRNA with the bacterial ribosome (44, 263). Therefore, to interact with their targets these molecules need to traverse one or more membrane systems depending on whether the susceptible organism is gram positive or gram negative.

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      ​ (Tables1 1 - Tetracycline Antibiotics: Mode of Action,...

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      ​ and2) 2 - Tetracycline Antibiotics: Mode of Action,...

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      Gastritis caused by Helicobacter pylori (tetracycline in...

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      Fig. 1 - Tetracycline Antibiotics: Mode of Action,...

  2. www.ncbi.nlm.nih.gov › pmc › articlesBacterial Protein Synthesis as a Target for Antibiotic ...

    The tetracycline family of antibiotics, including the third-generation glycylcyclines, such as tigecycline, bind to the SSU and sterically block the recognition of the codon of the mRNA by the anticodon of the aa-tRNA (Nguyen et al. 2014).

    • Stefan Arenz, Daniel N. Wilson
    • 10.1101/cshperspect.a025361
    • 2016
    • 2016/09

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  4. www.ncbi.nlm.nih.gov › books › NBK549905Tetracycline - StatPearls - NCBI Bookshelf

    Jun 5, 2023 · It involves the use of ribosomes, whose job is to translate an mRNA code into functioning proteins. In eukaryotes, this occurs on ribosomes with the 40S and 60S subunits. In prokaryotes, such as bacteria, protein synthesis occurs using ribosomes with the 30S and 50S subunits.

    • Mollie C. Shutter, Hossein Akhondi
    • 2023/06/05
    • Loyola, University of Nevada

  5. www.nature.com › articles › s41579/020/0386-zTarget protection as a key antibiotic resistance mechanism

    Jun 25, 2020 · Members of the tetracycline class of antibiotics inhibit bacterial translation by binding to the 30S ribosomal subunit and interfering with delivery of the incoming...

    • Daniel N. Wilson, Vasili Hauryliuk, Vasili Hauryliuk, Gemma C. Atkinson, Alex J. O’Neill
    • 2020

  6. www.nature.com › articles › s41467/021/24674-9Structural and mechanistic basis for translation ... - Nature

    Jul 22, 2021 · The ribosome and protein synthesis represent one of the major targets in the bacterial cell for clinically-relevant antibiotics 1,2.One important family of ribosome-targeting antibiotics are the ...

    • Bertrand Beckert, Elodie C. Leroy, Shanmugapriya Sothiselvam, Lars V. Bock, Maxim S. Svetlov, Michae...
    • 2021

  7. www.osmosis.org › learn › Protein_synthesisProtein synthesis inhibitors: Tetracyclines: Video | Osmosis

    In both eukaryotic and prokaryotic cells, protein synthesis involves initiation, elongation, and termination. In bacteria, initiation occurs when the 50S and 30S subunits bind to the mRNA sequence to form a ribosome-mRNA complex. The mRNA serves as a blueprint for the protein that will be synthesized.

  8. microbiology.weill.cornell.edu › tetracyclinesTetracyclines: antibiotic action, uptake, and resistance ...

    Tetracyclines probably penetrate bacterial cells by passive diffusion and inhibit bacterial growth by interfering with protein synthesis or by destroying the membrane. A growing number of various bacterial species acquire resistance to the bacteriostatic activity of tetracycline.

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