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- Multiple studies have demonstrated the efficacy of field-directed treatments, including 5-fluorouracil, photodynamic therapy, imiquimod, chemical exfoliation with trichloroacetic acid and diclofenac gel, for multiple AK and FC.
www.ncbi.nlm.nih.gov › pmc › articlesManagement Pearls on the Treatment of Actinic Keratoses and ...
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Feb 1, 2023 · Results: Efficacy data for various field therapies range widely, and long-term follow-up is limited. Cross-study comparisons are challenging because of heterogeneity of studies. Field-directed therapy with topical 5-fluorouracil and photodynamic therapy have similar effective cost.
Mar 6, 2019 · Generally, field-directed therapies are preferred, because they not only are therapeutically effective for present actinic keratosis but also may have a prophylactic effect on the development...
- Maud H E Jansen, Janneke P H M Kessels, Patty J Nelemans, Nina Kouloubis, Aimee H M M Arits, Han P A...
- 2019
Field-directed therapy is desirable for treating AKs due to the high recurrence rate for cutaneous squamous cell carcinoma (cSCC) when therapy is only lesion-directed. 4 Commonly used approaches of field therapy for AKs include 5-fluorouracil (5-FU), topical nonsteroidal anti-inflammatory drugs e.g., (diclofenac sodium, piroxicam), chemical peel...
Feb 19, 2022 · A recent study evaluated the efficacy of four treatments (5% imiquimod cream, methyl aminolevulinate PDT [MAL-PDT], 5% 5-FU cream, and 0.015% ingenol mebutate gel [IGM]) for AK located on the head and neck. Results showed that 5% 5-FU cream was the most effective among the field-directed treatments.
- 10.1007/s40257-022-00674-3
- 2022
- Am J Clin Dermatol. 2022; 23(3): 339-352.
Jun 7, 2021 · Analysis of the evidence resulted in 18 recommendations, suggesting there are several effective treatments available for AK. Limitations. The analysis informing the recommendations was based on the best available evidence at the time it was conducted. The results of future studies may necessitate a revision of current recommendations. Conclusions.
- Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Est...
- 2021
Field-directed therapy with topical 5-fluorouracil and photodynamic therapy have similar effective cost. Adherence may significantly affect real-world efficacy and long-term clearance; this would favor shorter duration topical regimens or in-office procedures.
Jul 17, 2020 · Multiple studies have demonstrated the efficacy of field-directed treatments, including 5-fluorouracil, photodynamic therapy, imiquimod, chemical exfoliation with trichloroacetic acid and diclofenac gel, for multiple AK and FC.
