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Jan 17, 2023 · Side effects from Paxlovid include a metallic taste in the mouth, diarrhea, nausea, and muscle aches, among others, but serious complications are uncommon.
- kathy.katella-cofrancesco@yale.edu
- How does Paxlovid work? Paxlovid is an antiviral therapy that consists of two separate medications packaged together. When you take your three-pill dose, two of those pills will be nirmatrelvir, which inhibits a key enzyme that the COVID virus requires in order to make functional virus particles.
- When should I take Paxlovid? You have to take Paxlovid within five days of developing symptoms. Like all antivirals, Paxlovid works best early in the course of an illness—in this case, within the first five days of symptom onset, says Jeffrey Topal, MD, a Yale Medicine infectious diseases specialist who is involved in determining COVID-19 treatment protocols for Yale New Haven Hospital patients.
- How often do I take Paxlovid? The standard dose is three Paxlovid pills twice daily for five days for a full course that adds up to 30 pills. It helps that the pills are packaged in a “dose card,” basically a medication blister pack that allows you to punch out the pills as needed.
- Is Paxlovid similar to Tamiflu? “I think it's a good comparison,” says Dr. Roberts. Tamiflu is an antiviral drug that reduces flu symptoms. Both are prescription-only oral antiviral pills given early in illness.
- EUA and NDA
- Studies
- Taste Changes
- Diarrhea
- Blood Pressure Increase
- Muscle Aches and Pain
- Severe Allergies
- Liver Problems
- Kidney Problems
- Resistance to HIV Medicines / Drug Interactions
Paxlovid has gone through several EUAs and is now fully approved for use in adults 18 years and older by the FDA. In December 2023, Pfizer will begin to fully manage the distribution of Paxlovid as the U.S. government transitions away from distribution of Paxlovid under the EUA. In addition, on Nov. 1, 2023 the FDA revised the EUA for pediatric pat...
Here, we’ll look at 8 key things you need to know about Paxlovid side effects and how you can best manage them. Always check with your healthcare provider about any side effects that are severe or that don’t go away. Additional side effect information for Paxlovid may become available with more widespread use. In studies, side effects were evaluate...
An altered or bad taste in the mouth is the most commonly reported side effect with Paxlovid. People report a bitter or metallic taste (often referred to as “Paxlovid mouth”) that’s hard to get rid of while on treatment. In studies, this side effect was shown to occur in about 6% of people who took Paxlovid (6 out of every 100 people). The good new...
Diarrhea is another side effect you may encounter during treatment with Paxlovid, but it’s also a side effect of COVID-19. For most people, diarrhea due to Paxlovid clears up after treatment and tends to be mild. Diarrhea with Paxlovid was infrequently reported in studies, occurring in 3% of people taking Paxlovid and 2% of people taking a placebo ...
High blood pressure was listed as a side effect with Paxlovid, but it’s not very common. High blood pressure, also called hypertension, occurred in about 1% of people (1 out of everyone 100) in Paxlovid studies (and less than 1% in the placebo group). If you already have high blood pressure or heart disease, this might be a serious side effect you ...
Muscle aches (myalgia) occurred in about 1% of people in studies with Paxlovid, and less than 1% of the placebo group. However, muscle aches and pains are a common symptom of COVID-19 and may appear about 2 to 14 days after exposure to the virus. Most people can treat minor aches and pains during COVID-19 or from Paxlovid treatment with over-the-co...
A severe allergy with Paxlovid treatment is not a common side effect, but, like any severe allergy it can be serious or even deadly. Rarely, severe allergic reactions (which may include anaphylaxis) can happen in people taking Paxlovid, even after taking only one dose. If you’ve had a severe allergic reaction to either active ingredient in Paxlovid...
Paxlovid may cause liver damage, but this has not been reported as a common side effect. In studies, increases in liver enzymes, hepatitis (inflammation of the liver), and jaundice (yellowing of skin, yellowing of the whites of the eyes) have been reported in patients taking ritonavir (Norvir), one of the active ingredients found in Paxlovid. If yo...
Blood levels of nirmatrelvir (one of the antivirals in Paxlovid) may increase in patients with certain levels of kidney disease. You should not use Paxlovid if you have severe kidney disease. A lower dose of Paxlovid is needed if you have moderate kidney disease. If needed, your doctor can order a simple blood test to determine how well your kidney...
If you have HIV that has not been treated or diagnosed, you may be at risk of developing resistance to HIV protease inhibitorantiviral medicines if you take Paxlovid. These HIV medicines may not work as well if you take them in the future. Talk to your doctor if you think you've been recently exposed to HIV before taking Paxlovid. You may need to t...
Aug 24, 2022 · Paxlovid Is Far More Effective in Seniors Than in People Under 65, Study Finds. 3 minute read. By Alice Park. August 24, 2022 7:48 PM EDT. T aking the antiviral treatment Paxlovid can reduce...
Jan 11, 2024 · Jan. 11, 2024. As hospitalizations and deaths from Covid-19 rise, fueled by a fast-moving new variant that now accounts for a majority of U.S. cases, Paxlovid can help protect patients from some...
- Dani Blum
Aug 15, 2022 · Paxlovid was 89% effective at reducing the risk of hospitalization or death, according to data from the clinical trial that led to the drug’s Emergency Use Authorization. These results were among 1,219 people ages 18 and older who were given Paxlovid within 3 days of experiencing COVID-19 symptoms.
Sep 6, 2022 · The efficacy of paxlovid in elderly patients infected with SARS-CoV-2 omicron variants: Results of a non-randomized clinical trial. Weijie Zhong, 1 , † Xiufeng Jiang, 1 , † Xiaosheng Yang, 1 , † Tiantong Feng, 2 Zhixin Duan, 1 Wei Wang, 1 Zhaoliang Sun, 1 Lingyan Chen, 3 Xin Nie, 4 Chuanlong Zhu, 2 , * Wenchuan Zhang, 1 , * and Yi Li 1 , *
